Phylogenomic analyses provide insights into primate evolution

Yong Shao, Long Zhou, Fang Li, Lan Zhao, Bao Lin Zhang, Feng Shao, Jia Wei Chen, Chun Yan Chen, Xupeng Bi, Xiao Lin Zhuang, Hong Liang Zhu, Jiang Hu, Zongyi Sun, Xin Li, Depeng Wang, Iker Rivas-González, Sheng Wang, Yun Mei Wang, Wu Chen, Gang LiHui Meng Lu, Yang Liu, Lukas F.K. Kuderna, Kyle Kai How Farh, Peng Fei Fan, Li Yu, Ming Li, Zhi Jin Liu, George P. Tiley, Anne D. Yoder, Christian Roos, Takashi Hayakawa, Tomas Marques-Bonet, Jeffrey Rogers, Peter D. Stenson, David N. Cooper, Mikkel Heide Schierup, Yong Gang Yao, Ya Ping Zhang, Wen Wang, Xiao Guang Qi, Guojie Zhang, Dong Dong Wu

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1 Citationer (Scopus)


Comparative analysis of primate genomes within a phylogenetic context is essential for understanding the evolution of human genetic architecture and primate diversity. We present such a study of 50 primate species spanning 38 genera and 14 families, including 27 genomes first reported here, with many from previously less well represented groups, the New World monkeys and the Strepsirrhini. Our analyses reveal heterogeneous rates of genomic rearrangement and gene evolution across primate lineages. Thousands of genes under positive selection in different lineages play roles in the nervous, skeletal, and digestive systems and may have contributed to primate innovations and adaptations. Our study reveals that many key genomic innovations occurred in the Simiiformes ancestral node and may have had an impact on the adaptive radiation of the Simiiformes and human evolution.

TidsskriftScience (New York, N.Y.)
Sider (fra-til)913-924
Antal sider12
StatusUdgivet - jun. 2023


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