Phenylethynylcobalamin: a light-stable and thermolysis-resistant organometallic vitamin B12 derivative prepared by radical synthesis

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

  • Markus Ruetz
  • ,
  • Robert Salchner
  • ,
  • Klaus Wurst
  • ,
  • Sergey Fedosov
  • Bernhard Kräutler
Don't take this antivitamin! 2-Phenylethynylcobalamin was prepared in a newly developed radical reaction using cob(II)alamin and 1-iodo-2-phenylethyne. It has an exceptionally short organometallic bond and is a remarkably light-stable and heat-resistant organometallic cobalamin. It is bound well by two important proteins of the human B12 transport system and has properties that are as expected for a new type of an "antivitamin B12 ".
OriginalsprogEngelsk
TidsskriftAngewandte Chemie International Edition
Vol/bind52
Nummer43
Sider (fra-til)11406-9
Antal sider4
ISSN1433-7851
DOI
StatusUdgivet - 18 okt. 2013

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