Pharmacokinetics of α-tocopherol stereoisomers in plasma and milk of cows following a single dose injection of all-rac-α-tocopheryl acetate

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Pharmacokinetics of α-tocopherol stereoisomers in plasma and milk of cows following a single dose injection of all-rac-α-tocopheryl acetate. / Jensen, S. K.; Lashkari, S.; Kristensen, N. B.

I: Food Chemistry, Bind 310, 125931, 25.04.2020.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

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@article{2e721f66419f4ade8295a5dc6e0f7149,
title = "Pharmacokinetics of α-tocopherol stereoisomers in plasma and milk of cows following a single dose injection of all-rac-α-tocopheryl acetate",
abstract = "Among different stereoisomers of all-rac-α-tocopherol, 2R-stereoisomers have higher biological activities than their 2S-stereoisomers. Two experiments were conducted to study the pharmacokinetics of stereoisomers of all-rac-α-tocopherol and investigated the discrimination and distribution of α-tocopherol stereoisomers in plasma and milk as well as quantitative secretion into milk with lactating Holstein cows after a single dose intramuscular injection of 2.50 g of all-rac-α-tocopheryl acetate. The highest half-life (2.92/h) and lowest elimination rate (0.36/h) were found for RRR-α-tocopherol. After a single dose injection of all-rac-α-tocopherol, highest maximal daily increase (Smax, 8.36 mg/day) and accumulation secretion (AS, 50.8 mg) were observed for milk RRR-α-tocopherol. The majority of the Ʃ2S stereoisomers were found in the liver 36 h post injection, while the 2R stereoisomers were more equal distributed between liver and plasma. The present findings showed a clear discrimination between RRR-α-tocopherol, synthetic 2R stereoisomers and Ʃ2S stereoisomers in milk and plasma of dairy cows.",
keywords = "Bioavailability, Biodiscrimination, Cows, Elimination rate, Half-life, Vitamin E",
author = "Jensen, {S. K.} and S. Lashkari and Kristensen, {N. B.}",
year = "2020",
month = "4",
day = "25",
doi = "10.1016/j.foodchem.2019.125931",
language = "English",
volume = "310",
journal = "Food Chemistry",
issn = "0308-8146",
publisher = "Elsevier BV",

}

RIS

TY - JOUR

T1 - Pharmacokinetics of α-tocopherol stereoisomers in plasma and milk of cows following a single dose injection of all-rac-α-tocopheryl acetate

AU - Jensen, S. K.

AU - Lashkari, S.

AU - Kristensen, N. B.

PY - 2020/4/25

Y1 - 2020/4/25

N2 - Among different stereoisomers of all-rac-α-tocopherol, 2R-stereoisomers have higher biological activities than their 2S-stereoisomers. Two experiments were conducted to study the pharmacokinetics of stereoisomers of all-rac-α-tocopherol and investigated the discrimination and distribution of α-tocopherol stereoisomers in plasma and milk as well as quantitative secretion into milk with lactating Holstein cows after a single dose intramuscular injection of 2.50 g of all-rac-α-tocopheryl acetate. The highest half-life (2.92/h) and lowest elimination rate (0.36/h) were found for RRR-α-tocopherol. After a single dose injection of all-rac-α-tocopherol, highest maximal daily increase (Smax, 8.36 mg/day) and accumulation secretion (AS, 50.8 mg) were observed for milk RRR-α-tocopherol. The majority of the Ʃ2S stereoisomers were found in the liver 36 h post injection, while the 2R stereoisomers were more equal distributed between liver and plasma. The present findings showed a clear discrimination between RRR-α-tocopherol, synthetic 2R stereoisomers and Ʃ2S stereoisomers in milk and plasma of dairy cows.

AB - Among different stereoisomers of all-rac-α-tocopherol, 2R-stereoisomers have higher biological activities than their 2S-stereoisomers. Two experiments were conducted to study the pharmacokinetics of stereoisomers of all-rac-α-tocopherol and investigated the discrimination and distribution of α-tocopherol stereoisomers in plasma and milk as well as quantitative secretion into milk with lactating Holstein cows after a single dose intramuscular injection of 2.50 g of all-rac-α-tocopheryl acetate. The highest half-life (2.92/h) and lowest elimination rate (0.36/h) were found for RRR-α-tocopherol. After a single dose injection of all-rac-α-tocopherol, highest maximal daily increase (Smax, 8.36 mg/day) and accumulation secretion (AS, 50.8 mg) were observed for milk RRR-α-tocopherol. The majority of the Ʃ2S stereoisomers were found in the liver 36 h post injection, while the 2R stereoisomers were more equal distributed between liver and plasma. The present findings showed a clear discrimination between RRR-α-tocopherol, synthetic 2R stereoisomers and Ʃ2S stereoisomers in milk and plasma of dairy cows.

KW - Bioavailability

KW - Biodiscrimination

KW - Cows

KW - Elimination rate

KW - Half-life

KW - Vitamin E

UR - http://www.scopus.com/inward/record.url?scp=85075992166&partnerID=8YFLogxK

U2 - 10.1016/j.foodchem.2019.125931

DO - 10.1016/j.foodchem.2019.125931

M3 - Journal article

C2 - 31835226

AN - SCOPUS:85075992166

VL - 310

JO - Food Chemistry

JF - Food Chemistry

SN - 0308-8146

M1 - 125931

ER -