Pharmacokinetics of the phosphatidylserine tracers 99mTc-lactadherin and 99mTc-annexin V in pigs

Runa H Poulsen; Jan T Rasmussen; June Anita Ejlersen; Christian Flø; Lise Falborg; Christian Würtz Heegaard; Michael Rehling

doi:10.1186/2191-219X-3-15

Pharmacokinetics of the phosphatidylserine tracers ^99mTc-lactadherin and ^99mTc-annexin V in pigs

Runa H Poulsen, Jan T Rasmussen, June Anita Ejlersen, Christian Flø, Lise Falborg, Christian Würtz Heegaard, Michael Rehling

Institut for Klinisk Medicin

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avis › Tidsskriftartikel › Forskning › peer review

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Abstract

Phosphatidylserine (PS) is a phospholipid normally located in the inner leaflet of the cell membrane. PS is translocated from the inner to the outer leaflet of the plasma membrane during the early stages of apoptosis and in necrosis. In cell and animal studies, reversible PS externalisation to the outer membrane leaflet has been observed in viable cells. Hence, PS markers have been proposed as markers of both reversibly and irreversibly damaged cells. The purpose of this experimental study in pigs was to investigate the kinetics of the newly introduced PS marker technetium-^99m-labelled lactadherin (^99mTc-lactadherin) in comparison with the well-known PS tracer 99mTc-annexin V with special reference to the renal handling of the tracers. The effective dose for humans was estimated from the biodistribution in 24 mice.

Originalsprog	Engelsk
Tidsskrift	EJNMMI research
Vol/bind	3
Nummer	15
Antal sider	9
ISSN	2191-219X
DOI	https://doi.org/10.1186/2191-219X-3-15
Status	Udgivet - 9 mar. 2013

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10.1186/2191-219X-3-15

Open access articleForlagets udgivne version, 414 KB

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@article{15a3f718efaa4720b6bf699eec247bf2,

title = "Pharmacokinetics of the phosphatidylserine tracers 99mTc-lactadherin and 99mTc-annexin V in pigs",

abstract = "Phosphatidylserine (PS) is a phospholipid normally located in the inner leaflet of the cell membrane. PS is translocated from the inner to the outer leaflet of the plasma membrane during the early stages of apoptosis and in necrosis. In cell and animal studies, reversible PS externalisation to the outer membrane leaflet has been observed in viable cells. Hence, PS markers have been proposed as markers of both reversibly and irreversibly damaged cells. The purpose of this experimental study in pigs was to investigate the kinetics of the newly introduced PS marker technetium-99m-labelled lactadherin (99mTc-lactadherin) in comparison with the well-known PS tracer 99mTc-annexin V with special reference to the renal handling of the tracers. The effective dose for humans was estimated from the biodistribution in 24 mice.",

keywords = "99mTc-lactadherin, Lactadherin, 99mTc-annexin V, Annexin V, Kinetics, Distribution, Clearance, Phosphatidylserine, Dosimetry",

author = "Poulsen, {Runa H} and Rasmussen, {Jan T} and Ejlersen, {June Anita} and Christian Fl{\o} and Lise Falborg and Heegaard, {Christian W{\"u}rtz} and Michael Rehling",

year = "2013",

month = mar,

day = "9",

doi = "10.1186/2191-219X-3-15",

language = "English",

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TY - JOUR

T1 - Pharmacokinetics of the phosphatidylserine tracers 99mTc-lactadherin and 99mTc-annexin V in pigs

AU - Poulsen, Runa H

AU - Rasmussen, Jan T

AU - Ejlersen, June Anita

AU - Flø, Christian

AU - Falborg, Lise

AU - Heegaard, Christian Würtz

AU - Rehling, Michael

PY - 2013/3/9

Y1 - 2013/3/9

N2 - Phosphatidylserine (PS) is a phospholipid normally located in the inner leaflet of the cell membrane. PS is translocated from the inner to the outer leaflet of the plasma membrane during the early stages of apoptosis and in necrosis. In cell and animal studies, reversible PS externalisation to the outer membrane leaflet has been observed in viable cells. Hence, PS markers have been proposed as markers of both reversibly and irreversibly damaged cells. The purpose of this experimental study in pigs was to investigate the kinetics of the newly introduced PS marker technetium-99m-labelled lactadherin (99mTc-lactadherin) in comparison with the well-known PS tracer 99mTc-annexin V with special reference to the renal handling of the tracers. The effective dose for humans was estimated from the biodistribution in 24 mice.

AB - Phosphatidylserine (PS) is a phospholipid normally located in the inner leaflet of the cell membrane. PS is translocated from the inner to the outer leaflet of the plasma membrane during the early stages of apoptosis and in necrosis. In cell and animal studies, reversible PS externalisation to the outer membrane leaflet has been observed in viable cells. Hence, PS markers have been proposed as markers of both reversibly and irreversibly damaged cells. The purpose of this experimental study in pigs was to investigate the kinetics of the newly introduced PS marker technetium-99m-labelled lactadherin (99mTc-lactadherin) in comparison with the well-known PS tracer 99mTc-annexin V with special reference to the renal handling of the tracers. The effective dose for humans was estimated from the biodistribution in 24 mice.

KW - 99mTc-lactadherin

KW - Lactadherin

KW - 99mTc-annexin V

KW - Annexin V

KW - Kinetics

KW - Distribution

KW - Clearance

KW - Phosphatidylserine

KW - Dosimetry

U2 - 10.1186/2191-219X-3-15

DO - 10.1186/2191-219X-3-15

M3 - Journal article

C2 - 23497537

SN - 2191-219X

VL - 3

JO - EJNMMI research

JF - EJNMMI research

IS - 15

ER -

Pharmacokinetics of the phosphatidylserine tracers 99mTc-lactadherin and 99mTc-annexin V in pigs

Abstract

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Citationsformater

Pharmacokinetics of the phosphatidylserine tracers ^99mTc-lactadherin and ^99mTc-annexin V in pigs