TY - JOUR
T1 - Periodontal infection and adverse pregnancy outcomes
T2 - A systematic review of epidemiological studies
AU - Vettore, Mario Vianna
AU - Lamarca, Gabriela De Almeida
AU - Leão, Anna Thereza Thomé
AU - Thomaz, Filipe Brand
AU - Sheiham, Aubrey
AU - Leal, Maria Do Carmo
PY - 2006
Y1 - 2006
N2 - The objective of this systematic review was to evaluate analytical studies on periodontal disease as a possible risk factor for adverse pregnancy outcomes. A literature search of the MEDLINE, SciELO, and LILACS bibliographic databases and CAPES thesis database was conducted up to December 2005, covering epidemiological studies of periodontal disease and adverse pregnancy outcomes. Of the 964 papers identified, 36 analytical studies met the inclusion criteria. Twenty-six epidemiological studies reported associations between periodontal disease and adverse pregnancy outcomes. There was a clear heterogeneity between studies concerning measurement of periodontal disease and selection of type of adverse pregnancy outcome. Therefore no meta-analysis was performed.Most studies did not control for confounders, thus raising serious doubts about their conclusions. The methodological limitations of most studies did not allow conclusions concerning the effects of periodontal disease on adverse pregnancy outcomes. Larger and methodologically rigorous analytical studies using reliable outcomes and exposure measures are recommended.
AB - The objective of this systematic review was to evaluate analytical studies on periodontal disease as a possible risk factor for adverse pregnancy outcomes. A literature search of the MEDLINE, SciELO, and LILACS bibliographic databases and CAPES thesis database was conducted up to December 2005, covering epidemiological studies of periodontal disease and adverse pregnancy outcomes. Of the 964 papers identified, 36 analytical studies met the inclusion criteria. Twenty-six epidemiological studies reported associations between periodontal disease and adverse pregnancy outcomes. There was a clear heterogeneity between studies concerning measurement of periodontal disease and selection of type of adverse pregnancy outcome. Therefore no meta-analysis was performed.Most studies did not control for confounders, thus raising serious doubts about their conclusions. The methodological limitations of most studies did not allow conclusions concerning the effects of periodontal disease on adverse pregnancy outcomes. Larger and methodologically rigorous analytical studies using reliable outcomes and exposure measures are recommended.
KW - Periodontal Diseases
KW - Pregnancy
KW - Review Literature
UR - http://www.scopus.com/inward/record.url?scp=33749544732&partnerID=8YFLogxK
U2 - 10.1590/S0102-311X2006001000010
DO - 10.1590/S0102-311X2006001000010
M3 - Review
C2 - 16951876
AN - SCOPUS:33749544732
SN - 0102-311X
VL - 22
SP - 2041
EP - 2053
JO - Cadernos de Saude Publica
JF - Cadernos de Saude Publica
IS - 10
ER -