Pattern recognition receptor polymorphisms in early periodontitis

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  • Fábio R M Leite
  • Christian Enevold, Institute for Inflammation Research,Center for Rheumatology and Spine Diseases,Copenhagen University Hospital, Danmark
  • Klaus Bendtzen, Institute for Inflammation Research,Center for Rheumatology and Spine Diseases,Copenhagen University Hospital, Danmark
  • Vibeke Baelum
  • Rodrigo López

BACKGROUND: Even though bacteria trigger inflammation, most of the tissue destruction in periodontitis is due to the host inflammatory response. In addition to immunological events that drive development of early periodontitis, numerous environmental factors like genetics and smoking play a role. We investigated whether the carriage of selected single nucleotide polymorphisms (SNP) of toll-like receptors (TLR), NOD-like receptors (NLR) and RIG-I-like receptors (RLR) was associated with the diagnosis of early periodontitis in a case-control study.

METHODS: Adolescents with positive (n = 87) and negative (n = 73) diagnosis for periodontitis had blood samples taken. All participants were genotyped for 42 SNP in the genes encoding TLR1-10, NOD1-2, DDX58, and IFIH1 using multiplex assays. Associations between SNP and periodontitis diagnosis were tested.

RESULTS: TLR1-rs5743611 showed protective effect for periodontitis (CC vs. GG and GC, P = 0.01, OR 0.10, 95%CI 0.01-0.78). Carriage of the TLR4-rs7873784 was associated with higher odds for periodontitis (GG vs. CC and GC, P = 0.05, OR 2.30, 95% CI 1.00-5.63; GG vs. GC, P = 0.05, OR 2.46, 95% CI 1.01-5.99). In male participants, reduced susceptibility to periodontitis was observed in carriers of TLR7-rs3853839 (CC vs. GG and CG, P = 0.02, OR 0.30, 95% CI 0.11-0.85) and TLR8-rs3764879 (CC vs. GG and CG, P = 0.02, OR 0.31, 95% CI 0.12-0.82). Associations were maintained after adjustments for sex, smoking habits and mother´s education.

CONCLUSIONS: This study demonstrated an association between TLR1-rs5743611, TLR4-rs7873784, TLR7-rs3853839 and TLR8-rs3764879 and susceptibility to periodontitis in adolescents. This article is protected by copyright. All rights reserved.

OriginalsprogEngelsk
TidsskriftJournal of Periodontology
ISSN0022-3492
DOI
StatusE-pub ahead of print - 5 dec. 2018

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This article is protected by copyright. All rights reserved.

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