Pathophysiology and management of diabetic gastroenteropathy

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisReviewForskningpeer review

DOI

  • Theresa Meldgaard, Mech-Sense, Department of Gastroenterology and Hepatology, Aalborg University Hospital, Aalborg, Denmark Department of Clinical Medicine, Aalborg University, Aalborg, Denmark
  • ,
  • Jutta Keller, Israelitic Hospital in Hamburg, Academic Hospital University of Hamburg, Germany.
  • ,
  • Anne Estrup Olesen, Mech-Sense, Department of Gastroenterology and Hepatology, Aalborg University Hospital, Aalborg, Denmark Department of Clinical Medicine, Aalborg University, Aalborg, Denmark
  • ,
  • Søren Schou Olesen, Mech-Sense, Department of Gastroenterology and Hepatology, Aalborg University Hospital, Aalborg, Denmark Department of Clinical Medicine, Aalborg University, Aalborg, Denmark
  • ,
  • Christina Brock
  • Asbjørn Mohr Drewes
  • Klaus Krogh
  • Mette Borre
  • Adam Farmer, Department of Gastroenterology, University Hospitals of North Midlands, Stoke-on-Trent, Staffordshire ST4 6QJ, UK.
  • ,
  • Birgitte Brock, Department of Clinical Research, Steno Diabetes Center Copenhagen (SDCC), Denmark.

Polyneuropathy is a common complication to diabetes. Neuropathies within the enteric nervous system are associated with gastroenteropathy and marked symptoms that severely reduce quality of life. Symptoms are pleomorphic but include nausea, vomiting, dysphagia, dyspepsia, pain, bloating, diarrhoea, constipation and faecal incontinence. The aims of this review are fourfold. First, to provide a summary of the pathophysiology underlying diabetic gastroenteropathy. Secondly to give an overview of the diagnostic methods. Thirdly, to provide clinicians with a focussed overview of current and future methods for pharmacological and nonpharmacological treatment modalities. Pharmacological management is categorised according to symptoms arising from the upper or lower gut as well as sensory dysfunctions. Dietary management is central to improvement of symptoms and is discussed in detail, and neuromodulatory treatment modalities and other emerging management strategies for diabetic gastroenteropathy are discussed. Finally, we propose a diagnostic/investigation algorithm that can be used to support multidisciplinary management.

OriginalsprogEngelsk
TidsskriftTherapeutic Advances in Gastroenterology
Vol/bind12
Sider (fra-til)1-17
Antal sider17
ISSN1756-283X
DOI
StatusUdgivet - jun. 2019

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