Paternal age and assisted reproductive technology: problem solver or trouble maker?

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisReviewForskningpeer review

Standard

Paternal age and assisted reproductive technology : problem solver or trouble maker? / Bertoncelli Tanaka, Mariana; Agarwal, Ashok; Esteves, Sandro C.

I: Panminerva medica, Bind 61, Nr. 2, 06.2019, s. 138-151.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisReviewForskningpeer review

Harvard

Bertoncelli Tanaka, M, Agarwal, A & Esteves, SC 2019, 'Paternal age and assisted reproductive technology: problem solver or trouble maker?', Panminerva medica, bind 61, nr. 2, s. 138-151. https://doi.org/10.23736/S0031-0808.18.03512-7

APA

Bertoncelli Tanaka, M., Agarwal, A., & Esteves, S. C. (2019). Paternal age and assisted reproductive technology: problem solver or trouble maker? Panminerva medica, 61(2), 138-151. https://doi.org/10.23736/S0031-0808.18.03512-7

CBE

Bertoncelli Tanaka M, Agarwal A, Esteves SC. 2019. Paternal age and assisted reproductive technology: problem solver or trouble maker?. Panminerva medica. 61(2):138-151. https://doi.org/10.23736/S0031-0808.18.03512-7

MLA

Bertoncelli Tanaka, Mariana, Ashok Agarwal og Sandro C. Esteves. "Paternal age and assisted reproductive technology: problem solver or trouble maker?". Panminerva medica. 2019, 61(2). 138-151. https://doi.org/10.23736/S0031-0808.18.03512-7

Vancouver

Bertoncelli Tanaka M, Agarwal A, Esteves SC. Paternal age and assisted reproductive technology: problem solver or trouble maker? Panminerva medica. 2019 jun;61(2):138-151. https://doi.org/10.23736/S0031-0808.18.03512-7

Author

Bertoncelli Tanaka, Mariana ; Agarwal, Ashok ; Esteves, Sandro C. / Paternal age and assisted reproductive technology : problem solver or trouble maker?. I: Panminerva medica. 2019 ; Bind 61, Nr. 2. s. 138-151.

Bibtex

@article{a4fa12b32e1546e2af9298d2a4816737,
title = "Paternal age and assisted reproductive technology: problem solver or trouble maker?",
abstract = "In our society, the number of couples with advanced reproductive age seeking fertility treatment is increasing steadily. While the negative effect of female age on assisted reproductive technology (ART) outcomes is well established, the impact of paternal age needs to be clarified. We reviewed the current literature to determine whether advanced paternal age affects the results of ART and the health of resulting offspring. We found that the published literature is overall supportive of a positive association between advanced paternal age (>40 years) and semen quality deterioration. However, the existing evidence does not corroborate nor discard the influence of advanced paternal age on ART outcomes. Similarly, the effect of paternal age on the health of ART offspring remains equivocal, although data from naturally-conceived children clearly indicates that advanced paternal age increases the frequency of genetic, neurodevelopmental, and psychiatric diseases in the progeny. Noteworthy, the current literature is limited and subjected to bias due to the impact of maternal age as a critical confounder. Health care providers should discuss with concerned couples the available options to counteract the possible negative influence of advanced paternal age on ART outcomes and health of resulting offspring. These include identification and treatment of underlying conditions with potential negative long-term effects on fertility, sperm freezing at a young age, and use of antioxidant supplements for men at risk of excessive oxidative stress. Aged male partner from couples undergoing ART, in particular men of 50 years and older, should consider use of preimplantation genetic testing as a means to detect embryo abnormalities and select euploid embryos for transfer to the uterine cavity.",
keywords = "Paternal age, Reproductive techniques, assisted, Fertilization in vitro, Sperm injections, intracytoplasmic, Infertility, male, SPERM DNA FRAGMENTATION, INTRACYTOPLASMIC SPERM, PREGNANCY OUTCOMES, INFERTILE MEN, INJECTION, QUALITY, ANEUPLOIDY, INTEGRITY, RATES, RISK",
author = "{Bertoncelli Tanaka}, Mariana and Ashok Agarwal and Esteves, {Sandro C.}",
year = "2019",
month = jun,
doi = "10.23736/S0031-0808.18.03512-7",
language = "English",
volume = "61",
pages = "138--151",
journal = "Panminerva medica",
issn = "0031-0808",
publisher = "Edizioni Minerva Medica S.p.A.",
number = "2",

}

RIS

TY - JOUR

T1 - Paternal age and assisted reproductive technology

T2 - problem solver or trouble maker?

AU - Bertoncelli Tanaka, Mariana

AU - Agarwal, Ashok

AU - Esteves, Sandro C.

PY - 2019/6

Y1 - 2019/6

N2 - In our society, the number of couples with advanced reproductive age seeking fertility treatment is increasing steadily. While the negative effect of female age on assisted reproductive technology (ART) outcomes is well established, the impact of paternal age needs to be clarified. We reviewed the current literature to determine whether advanced paternal age affects the results of ART and the health of resulting offspring. We found that the published literature is overall supportive of a positive association between advanced paternal age (>40 years) and semen quality deterioration. However, the existing evidence does not corroborate nor discard the influence of advanced paternal age on ART outcomes. Similarly, the effect of paternal age on the health of ART offspring remains equivocal, although data from naturally-conceived children clearly indicates that advanced paternal age increases the frequency of genetic, neurodevelopmental, and psychiatric diseases in the progeny. Noteworthy, the current literature is limited and subjected to bias due to the impact of maternal age as a critical confounder. Health care providers should discuss with concerned couples the available options to counteract the possible negative influence of advanced paternal age on ART outcomes and health of resulting offspring. These include identification and treatment of underlying conditions with potential negative long-term effects on fertility, sperm freezing at a young age, and use of antioxidant supplements for men at risk of excessive oxidative stress. Aged male partner from couples undergoing ART, in particular men of 50 years and older, should consider use of preimplantation genetic testing as a means to detect embryo abnormalities and select euploid embryos for transfer to the uterine cavity.

AB - In our society, the number of couples with advanced reproductive age seeking fertility treatment is increasing steadily. While the negative effect of female age on assisted reproductive technology (ART) outcomes is well established, the impact of paternal age needs to be clarified. We reviewed the current literature to determine whether advanced paternal age affects the results of ART and the health of resulting offspring. We found that the published literature is overall supportive of a positive association between advanced paternal age (>40 years) and semen quality deterioration. However, the existing evidence does not corroborate nor discard the influence of advanced paternal age on ART outcomes. Similarly, the effect of paternal age on the health of ART offspring remains equivocal, although data from naturally-conceived children clearly indicates that advanced paternal age increases the frequency of genetic, neurodevelopmental, and psychiatric diseases in the progeny. Noteworthy, the current literature is limited and subjected to bias due to the impact of maternal age as a critical confounder. Health care providers should discuss with concerned couples the available options to counteract the possible negative influence of advanced paternal age on ART outcomes and health of resulting offspring. These include identification and treatment of underlying conditions with potential negative long-term effects on fertility, sperm freezing at a young age, and use of antioxidant supplements for men at risk of excessive oxidative stress. Aged male partner from couples undergoing ART, in particular men of 50 years and older, should consider use of preimplantation genetic testing as a means to detect embryo abnormalities and select euploid embryos for transfer to the uterine cavity.

KW - Paternal age

KW - Reproductive techniques, assisted

KW - Fertilization in vitro

KW - Sperm injections, intracytoplasmic

KW - Infertility, male

KW - SPERM DNA FRAGMENTATION

KW - INTRACYTOPLASMIC SPERM

KW - PREGNANCY OUTCOMES

KW - INFERTILE MEN

KW - INJECTION

KW - QUALITY

KW - ANEUPLOIDY

KW - INTEGRITY

KW - RATES

KW - RISK

U2 - 10.23736/S0031-0808.18.03512-7

DO - 10.23736/S0031-0808.18.03512-7

M3 - Review

C2 - 30021419

VL - 61

SP - 138

EP - 151

JO - Panminerva medica

JF - Panminerva medica

SN - 0031-0808

IS - 2

ER -