TY - JOUR
T1 - Parental subfertility and hypospadias and cryptorchidism in boys
T2 - results from two Danish birth cohorts
AU - Arendt, Linn Håkonsen
AU - Lindhard, Morten Søndergaard
AU - Kjersgaard, Camilla
AU - Henriksen, Tine Brink
AU - Olsen, Jørn
AU - Ramlau-Hansen, Cecilia Høst
N1 - Copyright © 2018 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.
PY - 2018/10
Y1 - 2018/10
N2 - Objective: To study if parental subfertility is related to the occurrence of the male genital anomalies, cryptorchidism and hypospadias. Design: Population-based cohort study. Setting: Not applicable. Patient(s): A total of 80,220 singleton boys and their mothers from the Danish National Birth Cohort and the Aarhus Birth Cohort. Intervention(s): None. Main Outcome Measure(s): The two congenital anomalies; cryptorchidism and hypospadias, registered within the Danish National Patient Register up until December 31, 2012. Result(s): By means of Cox regression analyses, we found no associations between waiting time-to-pregnancy (TTP) and cryptorchidism or hypospadias among those who conceived spontaneously. The highest hazard ratio for cryptorchidism was seen among boys of couples with a TTP>12 months who conceived after fertility treatment (adjusted hazard ratio [aHR] 1.19, 95% confidence interval 0.92–1.55). For hypospadias, we found that boys of couples with a TTP>12 months who conceived after fertility treatment, had a 71% higher risk of hypospadias (aHR 1.71, [95% confidence interval 1.24–3.36]) as compared with boys of couples with a TTP<5 months. Conclusion(s): The findings from this study showed that boys of couples with TTP>12 months who conceived after fertility treatment, had a higher occurrence of hypospadias than boys conceived spontaneously of couples with a short TTP. Among those who conceived spontaneously, TTP was not associated with hypospadias or cryptorchidism. These findings indicate that fertility treatment or severity of subfertility is related to hypospadias.
AB - Objective: To study if parental subfertility is related to the occurrence of the male genital anomalies, cryptorchidism and hypospadias. Design: Population-based cohort study. Setting: Not applicable. Patient(s): A total of 80,220 singleton boys and their mothers from the Danish National Birth Cohort and the Aarhus Birth Cohort. Intervention(s): None. Main Outcome Measure(s): The two congenital anomalies; cryptorchidism and hypospadias, registered within the Danish National Patient Register up until December 31, 2012. Result(s): By means of Cox regression analyses, we found no associations between waiting time-to-pregnancy (TTP) and cryptorchidism or hypospadias among those who conceived spontaneously. The highest hazard ratio for cryptorchidism was seen among boys of couples with a TTP>12 months who conceived after fertility treatment (adjusted hazard ratio [aHR] 1.19, 95% confidence interval 0.92–1.55). For hypospadias, we found that boys of couples with a TTP>12 months who conceived after fertility treatment, had a 71% higher risk of hypospadias (aHR 1.71, [95% confidence interval 1.24–3.36]) as compared with boys of couples with a TTP<5 months. Conclusion(s): The findings from this study showed that boys of couples with TTP>12 months who conceived after fertility treatment, had a higher occurrence of hypospadias than boys conceived spontaneously of couples with a short TTP. Among those who conceived spontaneously, TTP was not associated with hypospadias or cryptorchidism. These findings indicate that fertility treatment or severity of subfertility is related to hypospadias.
KW - Congenital abnormalities
KW - infertility
KW - pregnancy
KW - reproductive techniques
KW - time-to-pregnancy
UR - http://www.scopus.com/inward/record.url?scp=85054424972&partnerID=8YFLogxK
U2 - 10.1016/j.fertnstert.2018.06.010
DO - 10.1016/j.fertnstert.2018.06.010
M3 - Journal article
C2 - 30316419
SN - 0015-0282
VL - 110
SP - 826
EP - 832
JO - Fertility and Sterility
JF - Fertility and Sterility
IS - 5
ER -