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Pappalysins and Stanniocalcins and Their Relationship With the Peripheral IGF Axis in Newborns and During Development

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avis › Tidsskriftartikel › Forskning › peer review

DOI

  • Álvaro Martín-Rivada, Universidad Autónoma de Madrid
    • ,
  • Santiago Guerra-Cantera, Universidad Autónoma de Madrid, Hospital Infantil Universitario Nino Jesus de Madrid
    • ,
  • Ana Campillo-Calatayud, Universidad Autónoma de Madrid
    • ,
  • Eva María Andrés-Esteban, Universidad Rey Juan Carlos
    • ,
  • María Sánchez Holgado, Universidad Autónoma de Madrid
    • ,
  • Gabriel Martos-Moreno, Universidad Autónoma de Madrid, Hospital Infantil Universitario Nino Jesus de Madrid
    • ,
  • Jesús Pozo, Hospital Infantil Universitario Nino Jesus de Madrid, Universidad Autónoma de Madrid
    • ,
  • María Güemes, Universidad Autónoma de Madrid
    • ,
  • Leandro Soriano-Guillén, Instituto de Investigación Fundación Jiménez Díaz
    • ,
  • Adelina Pellicer, Universidad Autónoma de Madrid
    • ,
  • Claus Oxvig
  • Jan Frystyk
  • Julie A. Chowen, Universidad Autónoma de Madrid, Hospital Infantil Universitario Nino Jesus de Madrid, IMDEA Food Institute
    • ,
  • Vicente Barrios, Universidad Autónoma de Madrid, Hospital Infantil Universitario Nino Jesus de Madrid
    • ,
  • Jesús Argente, Universidad Autónoma de Madrid, Hospital Infantil Universitario Nino Jesus de Madrid, IMDEA Food Institute

CONTEXT: Pappalysins (PAPP-A, PAPP-A2) modulate body growth by increasing insulin-like growth factor I (IGF-I) bioavailability through cleavage of insulin-like growth factor binding proteins (IGFBPs) and are inhibited by stanniocalcins (STC1, STC2). Normative data on these novel factors, as well as on free IGF-I and uncleaved fractions of IGFBPs, are not well established. OBJECTIVE: This work aimed to determine serum concentrations of PAPP-A, PAPP-A2, STC1, and STC2 in relationship with other growth hormone (GH)-IGF axis parameters during development. METHODS: Full-term newborns (150; gestational age: 39.30 ± 1.10 weeks), 40 preterm newborns (30.87 ± 3.35 weeks), and 1071 healthy individuals (aged 1-30 years) were included in the study and divided according to their Tanner stages (males and females): I:163 males, 154 females; II:100 males, 75 females; III:83 males, 96 females; IV: 77 males, 86 females; and V:109 males,128 females. RESULTS: Serum concentrations of PAPP-A, PAPP-A2, STC1, STC2, IGFBP-2, total IGFBP-4, and total IGFBP-5 were elevated at birth and declined throughout childhood. In postnatal life, PAPP-A2 concentrations decreased progressively in concomitance with the free/total IGF-I ratio; however, stanniocalcin concentrations remained stable. PAPP-A2 concentrations positively correlated with the free/total IGF-I ratio (r = +0.28; P < .001) and negatively with the intact/total IGFBP-3 ratio (r = -0.23; P < .001). PAPP-A concentrations inversely correlated with intact/total IGFBP-4 ratio (r = -0.21; P < .001), with PAPP-A concentrations being lower in females at all ages. Association studies indicate the importance of stanniocalcins and pappalysins in the control of this axis in an age-specific manner. CONCLUSION: This study provides reference values of pappalysins and stanniocalcins, which modulate IGF-I activity by changing the concentrations of cleaved and uncleaved IGFBPs.

OriginalsprogEngelsk
TidsskriftThe Journal of clinical endocrinology and metabolism
Vol/bind107
Nummer10
Sider (fra-til)2912-2924
Antal sider13
ISSN0021-972X
DOI
StatusUdgivet - okt. 2022

Bibliografisk note

Publisher Copyright:
© The Author(s) 2022. Published by Oxford University Press on behalf of the Endocrine Society. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

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