TY - JOUR
T1 - P-NGAL Day 1 predicts early but not one year graft function following deceased donor kidney transplantation - The CONTEXT study
AU - Bodilsen Nielsen, Marie
AU - Krogstrup, Nicoline Valentina
AU - Nieuwenhuijs-Moeke, Gertrude J
AU - Oltean, Mihai
AU - Dor, Frank J M F
AU - Jespersen, Bente
AU - Birn, Henrik
PY - 2019/2/28
Y1 - 2019/2/28
N2 - Background Early markers to predict delayed kidney graft function (DGF) may support clinical management. We studied the ability of four biomarkers (neutrophil gelatinase associated lipocalin (NGAL), liver-type fatty acid-binding protein (L-FABP), cystatin C, and YKL-40) to predict DGF after deceased donor transplantation, and their association with early graft function and GFR at three and twelve months. Methods 225 deceased donor kidney transplant recipients were included. Biomarkers were measured using automated assays or ELISA. We calculated their ability to predict the need for dialysis post-transplant and correlated with the estimated time to a 50% reduction in plasma creatinine (tCr50), measured glomerular filtration rate (mGFR) and estimated GFR (EGFR). Results All biomarkers measured at Day 1, except urinary L-FABP, significantly correlated with tCr50 and mGFR at Day 5. Plasma NGAL at Day 1 and a timed urine output predicted DGF (AUC = 0.91 and AUC 0.98). Nil or only weak correlations were identified between early biomarker levels and mGFR or EGFR at three or twelve months. Conclusion High plasma NGAL at Day 1 predicts DGF and is associated with initial graft function, but may not prove better than P-creatinine or a timed urine output. Early biomarker levels do not correlate with one-year graft function.
AB - Background Early markers to predict delayed kidney graft function (DGF) may support clinical management. We studied the ability of four biomarkers (neutrophil gelatinase associated lipocalin (NGAL), liver-type fatty acid-binding protein (L-FABP), cystatin C, and YKL-40) to predict DGF after deceased donor transplantation, and their association with early graft function and GFR at three and twelve months. Methods 225 deceased donor kidney transplant recipients were included. Biomarkers were measured using automated assays or ELISA. We calculated their ability to predict the need for dialysis post-transplant and correlated with the estimated time to a 50% reduction in plasma creatinine (tCr50), measured glomerular filtration rate (mGFR) and estimated GFR (EGFR). Results All biomarkers measured at Day 1, except urinary L-FABP, significantly correlated with tCr50 and mGFR at Day 5. Plasma NGAL at Day 1 and a timed urine output predicted DGF (AUC = 0.91 and AUC 0.98). Nil or only weak correlations were identified between early biomarker levels and mGFR or EGFR at three or twelve months. Conclusion High plasma NGAL at Day 1 predicts DGF and is associated with initial graft function, but may not prove better than P-creatinine or a timed urine output. Early biomarker levels do not correlate with one-year graft function.
UR - http://www.scopus.com/inward/record.url?scp=85062364993&partnerID=8YFLogxK
U2 - 10.1371/journal.pone.0212676
DO - 10.1371/journal.pone.0212676
M3 - Journal article
C2 - 30817778
SN - 1932-6203
VL - 14
JO - PLOS ONE
JF - PLOS ONE
IS - 2
M1 - e0212676
ER -