Ovarian stimulation and assisted reproductive technology outcomes in women transplanted with cryopreserved ovarian tissue: a systematic review

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Ovarian stimulation and assisted reproductive technology outcomes in women transplanted with cryopreserved ovarian tissue : a systematic review. / Andersen, Signe Taasti; Pors, Susanne Elisabeth; Poulsen, Liv la Cour; Colmorn, Lotte Berdiin; Macklon, Kirsten Tryde; Ernst, Erik; Humaidan, Peter; Andersen, Claus Yding; Kristensen, Stine Gry.

I: Fertility and Sterility, Bind 112, Nr. 5, 2019, s. 908-921.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

Harvard

Andersen, ST, Pors, SE, Poulsen, LLC, Colmorn, LB, Macklon, KT, Ernst, E, Humaidan, P, Andersen, CY & Kristensen, SG 2019, 'Ovarian stimulation and assisted reproductive technology outcomes in women transplanted with cryopreserved ovarian tissue: a systematic review', Fertility and Sterility, bind 112, nr. 5, s. 908-921. https://doi.org/10.1016/j.fertnstert.2019.07.008

APA

Andersen, S. T., Pors, S. E., Poulsen, L. L. C., Colmorn, L. B., Macklon, K. T., Ernst, E., ... Kristensen, S. G. (2019). Ovarian stimulation and assisted reproductive technology outcomes in women transplanted with cryopreserved ovarian tissue: a systematic review. Fertility and Sterility, 112(5), 908-921. https://doi.org/10.1016/j.fertnstert.2019.07.008

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MLA

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Author

Andersen, Signe Taasti ; Pors, Susanne Elisabeth ; Poulsen, Liv la Cour ; Colmorn, Lotte Berdiin ; Macklon, Kirsten Tryde ; Ernst, Erik ; Humaidan, Peter ; Andersen, Claus Yding ; Kristensen, Stine Gry. / Ovarian stimulation and assisted reproductive technology outcomes in women transplanted with cryopreserved ovarian tissue : a systematic review. I: Fertility and Sterility. 2019 ; Bind 112, Nr. 5. s. 908-921.

Bibtex

@article{8f09a783e8074e5d959df4a38936698f,
title = "Ovarian stimulation and assisted reproductive technology outcomes in women transplanted with cryopreserved ovarian tissue: a systematic review",
abstract = "OBJECTIVE: To systematically review reproductive outcomes of assisted reproductive technology (ART) treatment in women transplanted with frozen-thawed ovarian tissue.DESIGN: Systematic review in accordance with guidelines from Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA).SETTING: Not applicable.PATIENT(S): Women undergoing ovarian tissue transplantation (OTT) and subsequent ART.INTERVENTION(S): Literature search in PubMed and Scopus databases.MAIN OUTCOME MEASURE(S): Time from OTT to initiation of ART, stimulation protocol, and conventional ART outcome measures.RESULT(S): Twenty studies (including 15 case reports), specifying ART treatments and outcomes of 40 women undergoing OTT were identified. Multiple stimulation protocols were applied, with the modified natural cycle as the most frequently used. In total, 195 ART cycles were performed (4.0 cycles per patient) resulting in 1.5 follicles and 1.0 mature oocyte retrieved per cycle. Empty follicle rates ranged from 23{\%} to 35{\%} in the three largest cohort studies. Twenty-five women (62.5{\%}) had one or more pregnancies, of which 28.6{\%} were lost, resulting in a total of 20 live births (22 children). Overall the pregnancy rates varied from 3.9{\%} to 19.3{\%} and live-birth rates from 3.9{\%} to 14.0{\%} per cycle in the three cohort studies. Fertility treatment was initiated shortly after OTT in some centers, while others awaited natural conception before embarking on ART treatment.CONCLUSION(S): The reported pregnancy and live-birth rates for women undergoing OTT and ART were considerably lower than those of the general in vitro fertilization (IVF) population, corresponding to patients with poor ovarian reserve. In general, ART outcomes are underreported, and there is a lack of consensus regarding the timing of ART in relation to OTT and the type of ovarian stimulation protocol.",
keywords = "ART, autotransplantation, live-birth rate, ovarian stimulation, ovarian tissue cryopreservation",
author = "Andersen, {Signe Taasti} and Pors, {Susanne Elisabeth} and Poulsen, {Liv la Cour} and Colmorn, {Lotte Berdiin} and Macklon, {Kirsten Tryde} and Erik Ernst and Peter Humaidan and Andersen, {Claus Yding} and Kristensen, {Stine Gry}",
note = "Copyright {\circledC} 2019 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.",
year = "2019",
doi = "10.1016/j.fertnstert.2019.07.008",
language = "English",
volume = "112",
pages = "908--921",
journal = "Fertility and Sterility",
issn = "0015-0282",
publisher = "Elsevier Inc.",
number = "5",

}

RIS

TY - JOUR

T1 - Ovarian stimulation and assisted reproductive technology outcomes in women transplanted with cryopreserved ovarian tissue

T2 - a systematic review

AU - Andersen, Signe Taasti

AU - Pors, Susanne Elisabeth

AU - Poulsen, Liv la Cour

AU - Colmorn, Lotte Berdiin

AU - Macklon, Kirsten Tryde

AU - Ernst, Erik

AU - Humaidan, Peter

AU - Andersen, Claus Yding

AU - Kristensen, Stine Gry

N1 - Copyright © 2019 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.

PY - 2019

Y1 - 2019

N2 - OBJECTIVE: To systematically review reproductive outcomes of assisted reproductive technology (ART) treatment in women transplanted with frozen-thawed ovarian tissue.DESIGN: Systematic review in accordance with guidelines from Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA).SETTING: Not applicable.PATIENT(S): Women undergoing ovarian tissue transplantation (OTT) and subsequent ART.INTERVENTION(S): Literature search in PubMed and Scopus databases.MAIN OUTCOME MEASURE(S): Time from OTT to initiation of ART, stimulation protocol, and conventional ART outcome measures.RESULT(S): Twenty studies (including 15 case reports), specifying ART treatments and outcomes of 40 women undergoing OTT were identified. Multiple stimulation protocols were applied, with the modified natural cycle as the most frequently used. In total, 195 ART cycles were performed (4.0 cycles per patient) resulting in 1.5 follicles and 1.0 mature oocyte retrieved per cycle. Empty follicle rates ranged from 23% to 35% in the three largest cohort studies. Twenty-five women (62.5%) had one or more pregnancies, of which 28.6% were lost, resulting in a total of 20 live births (22 children). Overall the pregnancy rates varied from 3.9% to 19.3% and live-birth rates from 3.9% to 14.0% per cycle in the three cohort studies. Fertility treatment was initiated shortly after OTT in some centers, while others awaited natural conception before embarking on ART treatment.CONCLUSION(S): The reported pregnancy and live-birth rates for women undergoing OTT and ART were considerably lower than those of the general in vitro fertilization (IVF) population, corresponding to patients with poor ovarian reserve. In general, ART outcomes are underreported, and there is a lack of consensus regarding the timing of ART in relation to OTT and the type of ovarian stimulation protocol.

AB - OBJECTIVE: To systematically review reproductive outcomes of assisted reproductive technology (ART) treatment in women transplanted with frozen-thawed ovarian tissue.DESIGN: Systematic review in accordance with guidelines from Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA).SETTING: Not applicable.PATIENT(S): Women undergoing ovarian tissue transplantation (OTT) and subsequent ART.INTERVENTION(S): Literature search in PubMed and Scopus databases.MAIN OUTCOME MEASURE(S): Time from OTT to initiation of ART, stimulation protocol, and conventional ART outcome measures.RESULT(S): Twenty studies (including 15 case reports), specifying ART treatments and outcomes of 40 women undergoing OTT were identified. Multiple stimulation protocols were applied, with the modified natural cycle as the most frequently used. In total, 195 ART cycles were performed (4.0 cycles per patient) resulting in 1.5 follicles and 1.0 mature oocyte retrieved per cycle. Empty follicle rates ranged from 23% to 35% in the three largest cohort studies. Twenty-five women (62.5%) had one or more pregnancies, of which 28.6% were lost, resulting in a total of 20 live births (22 children). Overall the pregnancy rates varied from 3.9% to 19.3% and live-birth rates from 3.9% to 14.0% per cycle in the three cohort studies. Fertility treatment was initiated shortly after OTT in some centers, while others awaited natural conception before embarking on ART treatment.CONCLUSION(S): The reported pregnancy and live-birth rates for women undergoing OTT and ART were considerably lower than those of the general in vitro fertilization (IVF) population, corresponding to patients with poor ovarian reserve. In general, ART outcomes are underreported, and there is a lack of consensus regarding the timing of ART in relation to OTT and the type of ovarian stimulation protocol.

KW - ART

KW - autotransplantation

KW - live-birth rate

KW - ovarian stimulation

KW - ovarian tissue cryopreservation

U2 - 10.1016/j.fertnstert.2019.07.008

DO - 10.1016/j.fertnstert.2019.07.008

M3 - Journal article

C2 - 31594631

VL - 112

SP - 908

EP - 921

JO - Fertility and Sterility

JF - Fertility and Sterility

SN - 0015-0282

IS - 5

ER -