Outcomes following SARS-CoV-2 infection in individuals with and without solid organ transplantation-A Danish nationwide cohort study

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  • Maria Overvad, Department of Epidemiology Research & Department of Infectious Disease Epidemiology and Prevention
  • ,
  • Anders Koch, Statens Serum Institut, h Department of Infectious Diseases , Copenhagen University Hospital , Rigshospitalet , Denmark., University of Copenhagen, Danmark
  • Bente Jespersen
  • Finn Gustafsson, Department of Cardiology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark., Danmark
  • Tyra Grove Krause, Statens Serum Institut, Danmark
  • Christian Holm Hansen, Statens Serum Institut
  • ,
  • Steen Ethelberg, Statens Serum Institut, Danmark
  • Niels Obel, Statens Serum Institut, h Department of Infectious Diseases , Copenhagen University Hospital , Rigshospitalet , Denmark., Faculty of Health Sciences, Copenhagen, Danmark

The risk of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, hospitalization and death, and the effects of SARS-CoV-2 vaccines in solid organ transplant recipients (SOTRs) is still debated. We performed a nationwide, population-based, matched cohort study, including all Danish SOTRs (n = 5184) and a matched cohort from the general population (n = 41 472). Cox regression analyses were used to calculate incidence rate ratios (IRRs). SOTRs had a slightly increased risk of SARS-CoV-2 infection and were vaccinated earlier than the general population. The overall risk of hospital contact with COVID-19, severe COVID-19, need for assisted respiration, and hospitalization followed by death was substantially higher in SOTRs (IRR: 32.8 95%CI [29.0-37.0], 9.2 [6.7-12.7], 12.5 [7.6-20.8], 12.4 [7.9-12.7]). The risk of hospitalization and death after SARS-CoV-2 infection decreased substantially in SOTRs after the emergence of the Omicron variant (IRR: 0.45 [0.37-0.56], 0.17 [0.09-0.30]). Three vaccinations reduced the risk of SARS-CoV-2 infection only marginally compared to two vaccinations, but SOTRs with three vaccinations had a lower risk of death (IRR: 022 [0.16-0.35]). We conclude that SOTRs have a risk of SARS-CoV-2 infection comparable to the general population, but substantially increased the risk of hospitalization and death following SARS-CoV-2 infection. A third vaccination only reduces the risk of SARS-CoV2 infection marginally, but SOTRs vaccinated 3 times have reduced mortality.

OriginalsprogEngelsk
TidsskriftAmerican Journal of Transplantation
ISSN1600-6135
DOI
StatusE-pub ahead of print - 8 jul. 2022

Bibliografisk note

© 2022 The Authors. American Journal of Transplantation published by Wiley Periodicals LLC on behalf of The American Society of Transplantation and the American Society of Transplant Surgeons.

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