Aarhus University Seal / Aarhus Universitets segl

Organocatalytic Enantioselective 1,3-Dipolar [6+4] Cycloadditions of Tropone

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

DOI

A highly stereoselective 1,3-dipolar [6+4] cycloaddition towards bridged azabicyclo[4.3.1]decane scaffolds has been developed, reacting aldehydes, 2-aminomalonates and tropone under mild conditions in the presence of a chiral phosphoric acid catalyst. The scope is demonstrated for a series of aldehydes and 2-aminomalonates, and the reaction proceeds in high yields, >95:5 d.r. and up to 99 % ee. A series of transformations, as well as a mechanistic proposal, are presented.

OriginalsprogEngelsk
TidsskriftChemistry - A European Journal
Vol/bind26
Nummer67
Sider (fra-til)15491-15496
Antal sider6
ISSN0947-6539
DOI
StatusUdgivet - dec. 2020

Se relationer på Aarhus Universitet Citationsformater

ID: 202238347