Oral iron supplementation is not associated with short-term risk of infections: results from the Danish Blood Donor Study

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Oral iron supplementation is not associated with short-term risk of infections : results from the Danish Blood Donor Study. / Kaspersen, Kathrine Agergård; Dinh, Khoa Manh; Mikkelsen, Susan; Petersen, Mikkel Steen; Erikstrup, Lise Tornvig; Birger Pedersen, Ole; Sørensen, Erik; Hjalgrim, Henrik; Rigas, Andreas Stribolt; Nielsen, Kaspar René; Ullum, Henrik; Erikstrup, Christian.

I: Transfusion, Bind 59, Nr. 6, 06.2019, s. 2030-2038.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

Harvard

Kaspersen, KA, Dinh, KM, Mikkelsen, S, Petersen, MS, Erikstrup, LT, Birger Pedersen, O, Sørensen, E, Hjalgrim, H, Rigas, AS, Nielsen, KR, Ullum, H & Erikstrup, C 2019, 'Oral iron supplementation is not associated with short-term risk of infections: results from the Danish Blood Donor Study', Transfusion, bind 59, nr. 6, s. 2030-2038. https://doi.org/10.1111/trf.15221

APA

Kaspersen, K. A., Dinh, K. M., Mikkelsen, S., Petersen, M. S., Erikstrup, L. T., Birger Pedersen, O., Sørensen, E., Hjalgrim, H., Rigas, A. S., Nielsen, K. R., Ullum, H., & Erikstrup, C. (2019). Oral iron supplementation is not associated with short-term risk of infections: results from the Danish Blood Donor Study. Transfusion, 59(6), 2030-2038. https://doi.org/10.1111/trf.15221

CBE

Kaspersen KA, Dinh KM, Mikkelsen S, Petersen MS, Erikstrup LT, Birger Pedersen O, Sørensen E, Hjalgrim H, Rigas AS, Nielsen KR, Ullum H, Erikstrup C. 2019. Oral iron supplementation is not associated with short-term risk of infections: results from the Danish Blood Donor Study. Transfusion. 59(6):2030-2038. https://doi.org/10.1111/trf.15221

MLA

Vancouver

Author

Kaspersen, Kathrine Agergård ; Dinh, Khoa Manh ; Mikkelsen, Susan ; Petersen, Mikkel Steen ; Erikstrup, Lise Tornvig ; Birger Pedersen, Ole ; Sørensen, Erik ; Hjalgrim, Henrik ; Rigas, Andreas Stribolt ; Nielsen, Kaspar René ; Ullum, Henrik ; Erikstrup, Christian. / Oral iron supplementation is not associated with short-term risk of infections : results from the Danish Blood Donor Study. I: Transfusion. 2019 ; Bind 59, Nr. 6. s. 2030-2038.

Bibtex

@article{5f6434e4905445fa9ff6f3a1defeb1e6,
title = "Oral iron supplementation is not associated with short-term risk of infections: results from the Danish Blood Donor Study",
abstract = "BACKGROUND: Blood donors are at increased risk of developing iron deficiency, and several studies have recommended iron supplementation for this group. The aim of this study was to investigate the effect of oral iron supplementation on risk of infections among healthy blood donors. STUDY DESIGN AND METHODS: We included 82,062 participants from the Danish Blood Donor Study who completed a questionnaire on health-related items including use of oral iron supplementation. Infection outcomes were ascertained by using ICD-10 codes in the Danish National Patient Register and Anatomical Therapeutic Chemical codes in the Danish Prescription Register. Multivariable Cox proportional hazards analysis was used as the statistical model. Risk estimates are presented as crude hazard ratios (HRs) with 95% confidence intervals (CIs). RESULTS: During 19,978 person-years of observation, 6983 donors redeemed at least one prescription of antimicrobials. Similarly, during 19,829 person-years of observation, 242 donors were treated for infection at a hospital. Use of oral iron supplementation was not associated with redeemed prescriptions of antimicrobials in any strata: premenopausal women—HR 1.00, 95% CI 0.91-1.10; postmenopausal women—HR 1.07, 95% CI 0.87-1.32; and men—HR 1.01, 95% CI 0.84-1.21. In addition, use of oral iron supplementation was not associated with risk of hospital-based treatment for infection. CONCLUSION: In a large cohort of blood donors, use of oral iron supplementation was not associated with subsequent short-term risk of infection. These findings are important to help understanding the safety of using oral iron supplementation among blood donors and the general population.",
author = "Kaspersen, {Kathrine Agerg{\aa}rd} and Dinh, {Khoa Manh} and Susan Mikkelsen and Petersen, {Mikkel Steen} and Erikstrup, {Lise Tornvig} and {Birger Pedersen}, Ole and Erik S{\o}rensen and Henrik Hjalgrim and Rigas, {Andreas Stribolt} and Nielsen, {Kaspar Ren{\'e}} and Henrik Ullum and Christian Erikstrup",
year = "2019",
month = jun,
doi = "10.1111/trf.15221",
language = "English",
volume = "59",
pages = "2030--2038",
journal = "Transfusion",
issn = "0041-1132",
publisher = "Wiley-Blackwell Publishing, Inc.",
number = "6",

}

RIS

TY - JOUR

T1 - Oral iron supplementation is not associated with short-term risk of infections

T2 - results from the Danish Blood Donor Study

AU - Kaspersen, Kathrine Agergård

AU - Dinh, Khoa Manh

AU - Mikkelsen, Susan

AU - Petersen, Mikkel Steen

AU - Erikstrup, Lise Tornvig

AU - Birger Pedersen, Ole

AU - Sørensen, Erik

AU - Hjalgrim, Henrik

AU - Rigas, Andreas Stribolt

AU - Nielsen, Kaspar René

AU - Ullum, Henrik

AU - Erikstrup, Christian

PY - 2019/6

Y1 - 2019/6

N2 - BACKGROUND: Blood donors are at increased risk of developing iron deficiency, and several studies have recommended iron supplementation for this group. The aim of this study was to investigate the effect of oral iron supplementation on risk of infections among healthy blood donors. STUDY DESIGN AND METHODS: We included 82,062 participants from the Danish Blood Donor Study who completed a questionnaire on health-related items including use of oral iron supplementation. Infection outcomes were ascertained by using ICD-10 codes in the Danish National Patient Register and Anatomical Therapeutic Chemical codes in the Danish Prescription Register. Multivariable Cox proportional hazards analysis was used as the statistical model. Risk estimates are presented as crude hazard ratios (HRs) with 95% confidence intervals (CIs). RESULTS: During 19,978 person-years of observation, 6983 donors redeemed at least one prescription of antimicrobials. Similarly, during 19,829 person-years of observation, 242 donors were treated for infection at a hospital. Use of oral iron supplementation was not associated with redeemed prescriptions of antimicrobials in any strata: premenopausal women—HR 1.00, 95% CI 0.91-1.10; postmenopausal women—HR 1.07, 95% CI 0.87-1.32; and men—HR 1.01, 95% CI 0.84-1.21. In addition, use of oral iron supplementation was not associated with risk of hospital-based treatment for infection. CONCLUSION: In a large cohort of blood donors, use of oral iron supplementation was not associated with subsequent short-term risk of infection. These findings are important to help understanding the safety of using oral iron supplementation among blood donors and the general population.

AB - BACKGROUND: Blood donors are at increased risk of developing iron deficiency, and several studies have recommended iron supplementation for this group. The aim of this study was to investigate the effect of oral iron supplementation on risk of infections among healthy blood donors. STUDY DESIGN AND METHODS: We included 82,062 participants from the Danish Blood Donor Study who completed a questionnaire on health-related items including use of oral iron supplementation. Infection outcomes were ascertained by using ICD-10 codes in the Danish National Patient Register and Anatomical Therapeutic Chemical codes in the Danish Prescription Register. Multivariable Cox proportional hazards analysis was used as the statistical model. Risk estimates are presented as crude hazard ratios (HRs) with 95% confidence intervals (CIs). RESULTS: During 19,978 person-years of observation, 6983 donors redeemed at least one prescription of antimicrobials. Similarly, during 19,829 person-years of observation, 242 donors were treated for infection at a hospital. Use of oral iron supplementation was not associated with redeemed prescriptions of antimicrobials in any strata: premenopausal women—HR 1.00, 95% CI 0.91-1.10; postmenopausal women—HR 1.07, 95% CI 0.87-1.32; and men—HR 1.01, 95% CI 0.84-1.21. In addition, use of oral iron supplementation was not associated with risk of hospital-based treatment for infection. CONCLUSION: In a large cohort of blood donors, use of oral iron supplementation was not associated with subsequent short-term risk of infection. These findings are important to help understanding the safety of using oral iron supplementation among blood donors and the general population.

U2 - 10.1111/trf.15221

DO - 10.1111/trf.15221

M3 - Journal article

C2 - 30828821

VL - 59

SP - 2030

EP - 2038

JO - Transfusion

JF - Transfusion

SN - 0041-1132

IS - 6

ER -