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On the Origins of Diffusion MRI Signal Changes in Stroke

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On the Origins of Diffusion MRI Signal Changes in Stroke. / Blackband, Stephen J.; Flint, Jeremy; Hansen, Brian; Shepherd, Timothy M.; Heon-Lee, Choong; Streit, Wolfgang J. ; Forder, John.

I: Frontiers in Neurology, Bind 11, 549, 06.2020.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

Harvard

Blackband, SJ, Flint, J, Hansen, B, Shepherd, TM, Heon-Lee, C, Streit, WJ & Forder, J 2020, 'On the Origins of Diffusion MRI Signal Changes in Stroke', Frontiers in Neurology, bind 11, 549. https://doi.org/10.3389/fneur.2020.00549

APA

Blackband, S. J., Flint, J., Hansen, B., Shepherd, T. M., Heon-Lee, C., Streit, W. J., & Forder, J. (2020). On the Origins of Diffusion MRI Signal Changes in Stroke. Frontiers in Neurology, 11, [549]. https://doi.org/10.3389/fneur.2020.00549

CBE

Blackband SJ, Flint J, Hansen B, Shepherd TM, Heon-Lee C, Streit WJ, Forder J. 2020. On the Origins of Diffusion MRI Signal Changes in Stroke. Frontiers in Neurology. 11:Article 549. https://doi.org/10.3389/fneur.2020.00549

MLA

Vancouver

Blackband SJ, Flint J, Hansen B, Shepherd TM, Heon-Lee C, Streit WJ o.a. On the Origins of Diffusion MRI Signal Changes in Stroke. Frontiers in Neurology. 2020 jun;11. 549. https://doi.org/10.3389/fneur.2020.00549

Author

Blackband, Stephen J. ; Flint, Jeremy ; Hansen, Brian ; Shepherd, Timothy M. ; Heon-Lee, Choong ; Streit, Wolfgang J. ; Forder, John. / On the Origins of Diffusion MRI Signal Changes in Stroke. I: Frontiers in Neurology. 2020 ; Bind 11.

Bibtex

@article{311a986381474d86a095237d7a90b669,
title = "On the Origins of Diffusion MRI Signal Changes in Stroke",
abstract = "Magnetic resonance imaging (MRI) is a leading diagnostic technique especially for neurological studies. However, the physical origin of the hyperintense signal seen in MR images of stroke immediately after ischemic onset in the brain has been a matter of debate since it was first demonstrated in 1990. In this article, we hypothesize and provide evidence that changes in the glial cells, comprising roughly one-half of the brain's cells and therefore a significant share of its volume, accompanying ischemia, are the root cause of the MRI signal change. Indeed, a primary function of the glial cells is osmoregulation in order to maintain homeostasis in the neurons and nerve fibers for accurate and consistent function. This realization also impacts our understanding of signal changes in other tissues following ischemia. We anticipate that this paradigm shift will facilitate new and improved models of MRI signals in tissues, which will, in turn, impact clinical utility.",
keywords = "diffusion, glial cells, magnetic resonance (MR) imaging, magnetic resonance (MR) microscopy, stroke",
author = "Blackband, {Stephen J.} and Jeremy Flint and Brian Hansen and Shepherd, {Timothy M.} and Choong Heon-Lee and Streit, {Wolfgang J.} and John Forder",
year = "2020",
month = jun,
doi = "10.3389/fneur.2020.00549",
language = "English",
volume = "11",
journal = "Frontiers in Neurology",
issn = "1664-2295",
publisher = "Frontiers Research Foundation",

}

RIS

TY - JOUR

T1 - On the Origins of Diffusion MRI Signal Changes in Stroke

AU - Blackband, Stephen J.

AU - Flint, Jeremy

AU - Hansen, Brian

AU - Shepherd, Timothy M.

AU - Heon-Lee, Choong

AU - Streit, Wolfgang J.

AU - Forder, John

PY - 2020/6

Y1 - 2020/6

N2 - Magnetic resonance imaging (MRI) is a leading diagnostic technique especially for neurological studies. However, the physical origin of the hyperintense signal seen in MR images of stroke immediately after ischemic onset in the brain has been a matter of debate since it was first demonstrated in 1990. In this article, we hypothesize and provide evidence that changes in the glial cells, comprising roughly one-half of the brain's cells and therefore a significant share of its volume, accompanying ischemia, are the root cause of the MRI signal change. Indeed, a primary function of the glial cells is osmoregulation in order to maintain homeostasis in the neurons and nerve fibers for accurate and consistent function. This realization also impacts our understanding of signal changes in other tissues following ischemia. We anticipate that this paradigm shift will facilitate new and improved models of MRI signals in tissues, which will, in turn, impact clinical utility.

AB - Magnetic resonance imaging (MRI) is a leading diagnostic technique especially for neurological studies. However, the physical origin of the hyperintense signal seen in MR images of stroke immediately after ischemic onset in the brain has been a matter of debate since it was first demonstrated in 1990. In this article, we hypothesize and provide evidence that changes in the glial cells, comprising roughly one-half of the brain's cells and therefore a significant share of its volume, accompanying ischemia, are the root cause of the MRI signal change. Indeed, a primary function of the glial cells is osmoregulation in order to maintain homeostasis in the neurons and nerve fibers for accurate and consistent function. This realization also impacts our understanding of signal changes in other tissues following ischemia. We anticipate that this paradigm shift will facilitate new and improved models of MRI signals in tissues, which will, in turn, impact clinical utility.

KW - diffusion

KW - glial cells

KW - magnetic resonance (MR) imaging

KW - magnetic resonance (MR) microscopy

KW - stroke

U2 - 10.3389/fneur.2020.00549

DO - 10.3389/fneur.2020.00549

M3 - Journal article

C2 - 32714267

VL - 11

JO - Frontiers in Neurology

JF - Frontiers in Neurology

SN - 1664-2295

M1 - 549

ER -