Aarhus University Seal / Aarhus Universitets segl

On the Origins of Diffusion MRI Signal Changes in Stroke

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review


  • Stephen J. Blackband, University of Florida, National High Magnetic Field Laboratory, USA
  • Jeremy Flint, University of Florida, USA
  • Brian Hansen
  • Timothy M. Shepherd, New York University School of Medicine, USA
  • Choong Heon-Lee, New York University School of Medicine, USA
  • Wolfgang J. Streit, University of Florida
  • ,
  • John Forder, University of Florida, National High Magnetic Field Laboratory, USA

Magnetic resonance imaging (MRI) is a leading diagnostic technique especially for neurological studies. However, the physical origin of the hyperintense signal seen in MR images of stroke immediately after ischemic onset in the brain has been a matter of debate since it was first demonstrated in 1990. In this article, we hypothesize and provide evidence that changes in the glial cells, comprising roughly one-half of the brain's cells and therefore a significant share of its volume, accompanying ischemia, are the root cause of the MRI signal change. Indeed, a primary function of the glial cells is osmoregulation in order to maintain homeostasis in the neurons and nerve fibers for accurate and consistent function. This realization also impacts our understanding of signal changes in other tissues following ischemia. We anticipate that this paradigm shift will facilitate new and improved models of MRI signals in tissues, which will, in turn, impact clinical utility.

TidsskriftFrontiers in Neurology
Antal sider7
StatusUdgivet - jun. 2020

Se relationer på Aarhus Universitet Citationsformater

ID: 187370478