Obstructive Sleep Apnoea in Pycnodysostosis; A Three-Dmensional Upper Airway Analysis: Abstracts of Houston Oral and Poster Presentations and Scientific Posters

TY - ABST

T1 - Obstructive Sleep Apnoea in Pycnodysostosis; A Three-Dmensional Upper Airway Analysis

T2 - European Orthodontic Society <br/>Virtual Online Congress 2021

AU - Ferlias, Nikolaos

AU - Gjørup, Hans

AU - Aagaard Doherty, Mia

AU - Haagerup, Annette

AU - Pedersen, Thomas Klit

PY - 2021/10

Y1 - 2021/10

N2 - AIM: To assess the upper airway (UA) morphology in patients with pycnodysostosis with a threedimensional (3D) analysis, compare results with normative data and investigate correlation of the totalvolume (TV) to other UA morphology variables.MATERIALS AND METHOD: Cone beam computed tomography images of eight Danish patients withpycnodysostosis (4 males, 4 females with a mean age of 31.8 years, SD: 16.3 years), were analysed usingDownloaded from https://academic.oup.com/ejo/article/43/5/e1/6380769 by Aarhus University Library user on 10 December 2021e8Mimics® (Materialise®, Belgium) and compared with a gender- and age-matched control group (6 males, 8females with a mean age of 33.6 years, standard deviation: 18.6 years).RESULTS: The distance from the tip of the epiglottis to the Frankfort horizontal plane was significantlyshorter in the pycnodysostosis group (P < 0.042). Regarding the cross-sectional measurements, at‘maximum constriction’ (P < 0.005), the ‘upper airway limit’ (P < 0.001) and the ‘lower airway limit’ (P <0.035) cross-sections were significantly smaller in the pycnodysostosis group. The volumes nasopharynx (P <0.002) and total airway (P < 0.01) were also significantly smaller. A positive correlation was found betweenTV and all cross-sections as well as linear measurements.CONCLUSION: Patients with pycnodysostosis have a reduced total airway as well as nasopharyngeal volumecompared with matched controls. Additionally, they have a reduced cross-sectional area in the upper andlower borders of the UA, and the area of maximum constriction is also reduced. These factors could explainthe high prevalence of obstructive sleep apnoea in patients with pycnodysostosis. Total airway volume ispositively correlated to total length and cross-sections at all levels including the maximum constriction areaas well as the anteroposterior dimension at the upper and lower airway borders.

AB - AIM: To assess the upper airway (UA) morphology in patients with pycnodysostosis with a threedimensional (3D) analysis, compare results with normative data and investigate correlation of the totalvolume (TV) to other UA morphology variables.MATERIALS AND METHOD: Cone beam computed tomography images of eight Danish patients withpycnodysostosis (4 males, 4 females with a mean age of 31.8 years, SD: 16.3 years), were analysed usingDownloaded from https://academic.oup.com/ejo/article/43/5/e1/6380769 by Aarhus University Library user on 10 December 2021e8Mimics® (Materialise®, Belgium) and compared with a gender- and age-matched control group (6 males, 8females with a mean age of 33.6 years, standard deviation: 18.6 years).RESULTS: The distance from the tip of the epiglottis to the Frankfort horizontal plane was significantlyshorter in the pycnodysostosis group (P < 0.042). Regarding the cross-sectional measurements, at‘maximum constriction’ (P < 0.005), the ‘upper airway limit’ (P < 0.001) and the ‘lower airway limit’ (P <0.035) cross-sections were significantly smaller in the pycnodysostosis group. The volumes nasopharynx (P <0.002) and total airway (P < 0.01) were also significantly smaller. A positive correlation was found betweenTV and all cross-sections as well as linear measurements.CONCLUSION: Patients with pycnodysostosis have a reduced total airway as well as nasopharyngeal volumecompared with matched controls. Additionally, they have a reduced cross-sectional area in the upper andlower borders of the UA, and the area of maximum constriction is also reduced. These factors could explainthe high prevalence of obstructive sleep apnoea in patients with pycnodysostosis. Total airway volume ispositively correlated to total length and cross-sections at all levels including the maximum constriction areaas well as the anteroposterior dimension at the upper and lower airway borders.

U2 - 10.1093/ejo/cjab064

DO - 10.1093/ejo/cjab064

M3 - Conference abstract in journal

SN - 0141-5387

VL - 43

SP - e7

JO - European Journal of Orthodontics

JF - European Journal of Orthodontics

IS - 5

M1 - 10

Y2 - 2 July 2021 through 3 July 2021

ER -