Obstetric synthetic oxytocin use and subsequent hyperactivity/inattention problems in Danish children

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  • Lonny Stokholm, Environmental Epidemiology Group, Section of Environmental Health, Department of Public Health, University of Copenhagen, Denmark., Danmark
  • Mette Juhl, Faculty of Health and Technology, Department of Nutrition and Midwifery, Metropolitan University College, Copenhagen, Denmark., Department of Public Health, University of Copenhagen, Copenhagen, Denmark.
  • ,
  • Nicole N Lønfeldt, Child and Adolescent Mental Health Centre, Mental Health Services Capital Region, Research Unit, Copenhagen University Hospital, Copenhagen, Denmark; The Lundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH), Aarhus, Denmark; Division of Child and Adolescent Psychiatry, Department of Psychiatry, Lausanne University Hospital, Lausanne, Switzerland., Danmark
  • Susanne H Mikkelsen
  • ,
  • Carsten Obel
  • Katrine Strandberg-Larsen, Environmental Epidemiology Group, Section of Environmental Health, Department of Public Health, University of Copenhagen, Denmark.

INTRODUCTION: The objective was to examine the association between obstetric synthetic oxytocin use and hyperactivity/inattention problems in offspring.

MATERIAL AND METHODS: We identified children born in 2000-2003, enrolled in the Danish National Birth Cohort, with data on the Strengths and Difficulties Questionnaire (SDQ) reported by parents at age seven (n = 33 896) and age 11 (n = 27 561) and the children themselves around age 11 (n = 27 251). Information on oxytocin administration was provided in the Medical Birth Register. We estimated mean differences and odds ratios for childhood hyperactivity/inattention problems according to oxytocin exposure.

RESULTS: Synthetic oxytocin was administered in 26% of the deliveries. We did not find the use of synthetic oxytocin during birth to be associated with childhood hyperactivity/inattention problems, whether analyzed in linear or logistic regression models.

CONCLUSIONS: Our findings do not support any effects of obstetric use of synthetic oxytocin on hyperactivity/inattention problems in children when measured with the SDQ subscale at 7 or 11 years of age.

OriginalsprogEngelsk
TidsskriftActa Obstetricia et Gynecologica Scandinavica
Vol/bind97
Nummer7
Sider (fra-til)880-889
Antal sider10
ISSN0001-6349
DOI
StatusUdgivet - 1 jul. 2018

Bibliografisk note

© 2018 Nordic Federation of Societies of Obstetrics and Gynecology.

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