Obsessive-compulsive symptom dimensions: Association with comorbidity profiles and cognitive-behavioral therapy outcome in pediatric obsessive-compulsive disorder

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

  • David R.M.A. Højgaard
  • Katja A Hybel
  • Erik Lykke Mortensen, Københavns Universitet, Danmark
  • Tord Ivarsson, Eastern and Southern Norway, Norge
  • Judith Becker Nissen
  • Bernhard Weidle, Norwegian University of Science and Technology, Norge
  • Karin Melin, Sahlgrenska University Hospital, Sverige
  • Nor Christian Torp, Eastern and Southern Norway, Vestre Viken Hospital Trust, Norge
  • Kitty Dahl, Eastern and Southern Norway, Norge
  • Robert Valderhaug, Norwegian University of Science and Technology, Norge
  • Gudmundur Skarphedinsson, University of Iceland, Island
  • Eric A Storch, Baylor College of Medicine, Rogers Behavioral Health, Johns Hopkins All Children's Hospital, USA
  • Per Hove Thomsen

Our aims were to examine: (1) classes of comorbid disorders in a sample of children and adolescents with Obsessive-Compulsive Disorder (OCD), (2) how these classes relate to obsessive-compulsive symptom dimensions, and (3) the extent to which obsessive-compulsive symptom dimensions predict Cognitive-Behavioral Therapy (CBT) outcome. Participants (N = 269) were assessed with the Kiddie Schedule for Affective Disorders and Schizophrenia (K-SADS-PL) and the Children's Yale-Brown Obsessive-Compulsive Scale (CY-BOCS). Latent Class Analysis (LCA) was used to identify comorbidity classes. Regression analyses were used to evaluate symptom dimensions as predictors of treatment outcome and their relation to comorbidity classes. Comorbidity was included in the treatment outcome analyses as it can affect outcome. Comorbidity was best categorized by a three-class model and each class was distinctively correlated with the OCD symptom dimensions. Higher scores on the symmetry/hoarding factor increased the chance of responding to CBT by an odds ratio of 1.56 (p = 0.020) when controlled for age, gender, and comorbidity class. The harm/sexual factor (p = 0.675) and contamination/cleaning factor (p = 0.122) did not predict CBT outcome. Three clinically relevant comorbidity subgroups in pediatric OCD were identified. Patients who exhibited higher levels of symmetry/hoarding dimension were more prone to respond to CBT.

TidsskriftPsychiatry Research
Sider (fra-til)317-323
Antal sider7
StatusUdgivet - 2018

Bibliografisk note

Copyright © 2018 Elsevier B.V. All rights reserved.

Se relationer på Aarhus Universitet Citationsformater

ID: 136631300