Nucleic Acids as a Nature-Inspired Scaffold for Macromolecular Prodrugs of Nucleoside Analogues

Franziska Krüger, Vipin Kumar, Pere Monge, Carina Conzelmann, Nikaïa Smith, Kurt V. Gothelf, Martin Tolstrup, Jan Münch*, Alexander N. Zelikin

*Corresponding author af dette arbejde

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

4 Citationer (Scopus)

Abstract

Macromolecular prodrugs (MP) built on the natural phosphodiester and deoxyribose backbone are developed using marketed antiviral nucleoside analogues. These MP are synthesized using automated synthesis, have defined molecular composition, and have a natural mechanism for drug release. These unique attributes, coupled to the efficient cell entry and potent antiviral effects, position the prodrugs scaffolded on nucleic acids favorably for translational studies.

OriginalsprogEngelsk
Artikelnummer1802095
TidsskriftAdvanced Science
Vol/bind6
Nummer6
DOI
StatusUdgivet - 2019

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