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Novel phosphine sulphide gold(i) complexes: topoisomerase I inhibitors and antiproliferative agents

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Novel phosphine sulphide gold(i) complexes : topoisomerase I inhibitors and antiproliferative agents. / Martín-Encinas, Endika; Conejo-Rodríguez, Verónica; Miguel, Jesús A.; Martínez-Ilarduya, Jesús M.; Rubiales, Gloria; Knudsen, Birgitta R.; Palacios, Francisco; Alonso, Concepción.

I: Dalton Transactions, Bind 49, Nr. 23, 2020, s. 7852-7861.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

Harvard

Martín-Encinas, E, Conejo-Rodríguez, V, Miguel, JA, Martínez-Ilarduya, JM, Rubiales, G, Knudsen, BR, Palacios, F & Alonso, C 2020, 'Novel phosphine sulphide gold(i) complexes: topoisomerase I inhibitors and antiproliferative agents', Dalton Transactions, bind 49, nr. 23, s. 7852-7861. https://doi.org/10.1039/d0dt01467b

APA

Martín-Encinas, E., Conejo-Rodríguez, V., Miguel, J. A., Martínez-Ilarduya, J. M., Rubiales, G., Knudsen, B. R., Palacios, F., & Alonso, C. (2020). Novel phosphine sulphide gold(i) complexes: topoisomerase I inhibitors and antiproliferative agents. Dalton Transactions, 49(23), 7852-7861. https://doi.org/10.1039/d0dt01467b

CBE

Martín-Encinas E, Conejo-Rodríguez V, Miguel JA, Martínez-Ilarduya JM, Rubiales G, Knudsen BR, Palacios F, Alonso C. 2020. Novel phosphine sulphide gold(i) complexes: topoisomerase I inhibitors and antiproliferative agents. Dalton Transactions. 49(23):7852-7861. https://doi.org/10.1039/d0dt01467b

MLA

Vancouver

Martín-Encinas E, Conejo-Rodríguez V, Miguel JA, Martínez-Ilarduya JM, Rubiales G, Knudsen BR o.a. Novel phosphine sulphide gold(i) complexes: topoisomerase I inhibitors and antiproliferative agents. Dalton Transactions. 2020;49(23):7852-7861. https://doi.org/10.1039/d0dt01467b

Author

Martín-Encinas, Endika ; Conejo-Rodríguez, Verónica ; Miguel, Jesús A. ; Martínez-Ilarduya, Jesús M. ; Rubiales, Gloria ; Knudsen, Birgitta R. ; Palacios, Francisco ; Alonso, Concepción. / Novel phosphine sulphide gold(i) complexes : topoisomerase I inhibitors and antiproliferative agents. I: Dalton Transactions. 2020 ; Bind 49, Nr. 23. s. 7852-7861.

Bibtex

@article{79160864caa6467e91a59d764493efa1,
title = "Novel phosphine sulphide gold(i) complexes: topoisomerase I inhibitors and antiproliferative agents",
abstract = "This work describes the synthesis of the gold(i) complexes of phosphine sulphides. The formation of these new derivatives has been confirmed by X-ray crystallography. The coordination of gold(i) with the sulphur atom of the phosphine sulphides favors the inhibition of topoisomerase I as well as a high cytotoxicity of the gold(i)-complexed compounds against the cancer line A549 with IC50values in the nanomolar range and IC50values below 5 μM against the SKOV3 cell line. It should be noted that the cytotoxicities observed for the new gold(i) complexes are higher than those observed for phosphine sulphide ligands before binding to gold. Furthermore, the results also indicate that the presence of a nitrogenated heterocycle, such as tetrahydroquinoline or quinoline, is also necessary for the TopI inhibition to be maintained. In addition, no toxicity was observed when the non-cancerous lung fibroblast cell line (MRC5) was treated with the new phosphine sulphide gold(i) complexes prepared.",
author = "Endika Mart{\'i}n-Encinas and Ver{\'o}nica Conejo-Rodr{\'i}guez and Miguel, {Jes{\'u}s A.} and Mart{\'i}nez-Ilarduya, {Jes{\'u}s M.} and Gloria Rubiales and Knudsen, {Birgitta R.} and Francisco Palacios and Concepci{\'o}n Alonso",
year = "2020",
doi = "10.1039/d0dt01467b",
language = "English",
volume = "49",
pages = "7852--7861",
journal = "Dalton Transactions (Print Edition)",
issn = "1477-9226",
publisher = "MUNKSGAARD INT PUBL LTD",
number = "23",

}

RIS

TY - JOUR

T1 - Novel phosphine sulphide gold(i) complexes

T2 - topoisomerase I inhibitors and antiproliferative agents

AU - Martín-Encinas, Endika

AU - Conejo-Rodríguez, Verónica

AU - Miguel, Jesús A.

AU - Martínez-Ilarduya, Jesús M.

AU - Rubiales, Gloria

AU - Knudsen, Birgitta R.

AU - Palacios, Francisco

AU - Alonso, Concepción

PY - 2020

Y1 - 2020

N2 - This work describes the synthesis of the gold(i) complexes of phosphine sulphides. The formation of these new derivatives has been confirmed by X-ray crystallography. The coordination of gold(i) with the sulphur atom of the phosphine sulphides favors the inhibition of topoisomerase I as well as a high cytotoxicity of the gold(i)-complexed compounds against the cancer line A549 with IC50values in the nanomolar range and IC50values below 5 μM against the SKOV3 cell line. It should be noted that the cytotoxicities observed for the new gold(i) complexes are higher than those observed for phosphine sulphide ligands before binding to gold. Furthermore, the results also indicate that the presence of a nitrogenated heterocycle, such as tetrahydroquinoline or quinoline, is also necessary for the TopI inhibition to be maintained. In addition, no toxicity was observed when the non-cancerous lung fibroblast cell line (MRC5) was treated with the new phosphine sulphide gold(i) complexes prepared.

AB - This work describes the synthesis of the gold(i) complexes of phosphine sulphides. The formation of these new derivatives has been confirmed by X-ray crystallography. The coordination of gold(i) with the sulphur atom of the phosphine sulphides favors the inhibition of topoisomerase I as well as a high cytotoxicity of the gold(i)-complexed compounds against the cancer line A549 with IC50values in the nanomolar range and IC50values below 5 μM against the SKOV3 cell line. It should be noted that the cytotoxicities observed for the new gold(i) complexes are higher than those observed for phosphine sulphide ligands before binding to gold. Furthermore, the results also indicate that the presence of a nitrogenated heterocycle, such as tetrahydroquinoline or quinoline, is also necessary for the TopI inhibition to be maintained. In addition, no toxicity was observed when the non-cancerous lung fibroblast cell line (MRC5) was treated with the new phosphine sulphide gold(i) complexes prepared.

UR - http://www.scopus.com/inward/record.url?scp=85086506428&partnerID=8YFLogxK

U2 - 10.1039/d0dt01467b

DO - 10.1039/d0dt01467b

M3 - Journal article

C2 - 32463416

AN - SCOPUS:85086506428

VL - 49

SP - 7852

EP - 7861

JO - Dalton Transactions (Print Edition)

JF - Dalton Transactions (Print Edition)

SN - 1477-9226

IS - 23

ER -