Novel methodology to enrich medium- and short-chain fatty acids in milk fat to improve metabolic health

Sally Samsø Mathiasen; Josephine  M. Kanta; Rikke Ploug Frydenberg; Annemarie   Lundsgaard; Zheng Guo; Andreas  M. Fritzen; Bente Kiens; Lars Wiking; Maximilian Kleinert

doi:10.1039/D4FO00267A

Novel methodology to enrich medium- and short-chain fatty acids in milk fat to improve metabolic health

Sally Samsø Mathiasen, Josephine M. Kanta, Rikke Ploug Frydenberg, Annemarie Lundsgaard, Zheng Guo, Andreas M. Fritzen, Bente Kiens^*, Lars Wiking^*, Maximilian Kleinert^*

^*Corresponding author af dette arbejde

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avis › Tidsskriftartikel › Forskning › peer review

5 Citationer (Scopus)

Abstract

Dietary short- and medium-chain fatty acids have been shown to elevate circulating ketone bodies and confer metabolic health benefits. Cow milk fat contains these lipids in a balanced mix but in relatively low concentrations. Enriching them could amplify health benefits of dairy products. Here, we used a volatility-based workflow to produce milk fat with a 2-fold enrichment of medium- and short-chain fatty acids (referred to as MSFAT). Our proof-of-concept studies in mice demonstrated that intake of MSFAT increased circulating ketone bodies, reduced blood glucose levels, and suppressed food intake. In humans, ingestion of MSFAT resulted in increased circulating ketone bodies, trended to attenuate (p = 0.07) postprandial glucose excursion, and acutely elevated energy expenditure. Our findings show that milk products enriched with MSFAT may hold significant metabolic advantages.

Originalsprog	Engelsk
Tidsskrift	Food & Function
Vol/bind	15
Nummer	15
Sider (fra-til)	7951-7960
Antal sider	10
ISSN	2042-6496
DOI	https://doi.org/10.1039/D4FO00267A https://doi.org/10.1039/d4fo00267a
Status	Udgivet - 29 jul. 2024

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title = "Novel methodology to enrich medium- and short-chain fatty acids in milk fat to improve metabolic health",

abstract = "Dietary short- and medium-chain fatty acids have been shown to elevate circulating ketone bodies and confer metabolic health benefits. Cow milk fat contains these lipids in a balanced mix but in relatively low concentrations. Enriching them could amplify health benefits of dairy products. Here, we used a volatility-based workflow to produce milk fat with a 2-fold enrichment of medium- and short-chain fatty acids (referred to as MSFAT). Our proof-of-concept studies in mice demonstrated that intake of MSFAT increased circulating ketone bodies, reduced blood glucose levels, and suppressed food intake. In humans, ingestion of MSFAT resulted in increased circulating ketone bodies, trended to attenuate (p = 0.07) postprandial glucose excursion, and acutely elevated energy expenditure. Our findings show that milk products enriched with MSFAT may hold significant metabolic advantages.",

author = "Mathiasen, {Sally Sams{\o}} and {M. Kanta}, Josephine and {Ploug Frydenberg}, Rikke and Annemarie Lundsgaard and Zheng Guo and {M. Fritzen}, Andreas and Bente Kiens and Lars Wiking and Maximilian Kleinert",

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Novel methodology to enrich medium- and short-chain fatty acids in milk fat to improve metabolic health. / Mathiasen, Sally Samsø; M. Kanta, Josephine; Ploug Frydenberg, Rikke et al.
I: Food & Function, Bind 15, Nr. 15, 29.07.2024, s. 7951-7960.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avis › Tidsskriftartikel › Forskning › peer review

TY - JOUR

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AU - Mathiasen, Sally Samsø

AU - M. Kanta, Josephine

AU - Ploug Frydenberg, Rikke

AU - Lundsgaard, Annemarie

AU - Guo, Zheng

AU - M. Fritzen, Andreas

AU - Kiens, Bente

AU - Wiking, Lars

AU - Kleinert, Maximilian

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Y1 - 2024/7/29

N2 - Dietary short- and medium-chain fatty acids have been shown to elevate circulating ketone bodies and confer metabolic health benefits. Cow milk fat contains these lipids in a balanced mix but in relatively low concentrations. Enriching them could amplify health benefits of dairy products. Here, we used a volatility-based workflow to produce milk fat with a 2-fold enrichment of medium- and short-chain fatty acids (referred to as MSFAT). Our proof-of-concept studies in mice demonstrated that intake of MSFAT increased circulating ketone bodies, reduced blood glucose levels, and suppressed food intake. In humans, ingestion of MSFAT resulted in increased circulating ketone bodies, trended to attenuate (p = 0.07) postprandial glucose excursion, and acutely elevated energy expenditure. Our findings show that milk products enriched with MSFAT may hold significant metabolic advantages.

AB - Dietary short- and medium-chain fatty acids have been shown to elevate circulating ketone bodies and confer metabolic health benefits. Cow milk fat contains these lipids in a balanced mix but in relatively low concentrations. Enriching them could amplify health benefits of dairy products. Here, we used a volatility-based workflow to produce milk fat with a 2-fold enrichment of medium- and short-chain fatty acids (referred to as MSFAT). Our proof-of-concept studies in mice demonstrated that intake of MSFAT increased circulating ketone bodies, reduced blood glucose levels, and suppressed food intake. In humans, ingestion of MSFAT resulted in increased circulating ketone bodies, trended to attenuate (p = 0.07) postprandial glucose excursion, and acutely elevated energy expenditure. Our findings show that milk products enriched with MSFAT may hold significant metabolic advantages.

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U2 - 10.1039/D4FO00267A

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JO - Food & Function

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Novel methodology to enrich medium- and short-chain fatty acids in milk fat to improve metabolic health

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