TY - JOUR
T1 - Novel genetic variation associated to CSN3 strongly affects rennet-induced milk coagulation
AU - Poulsen, Nina Aagaard
AU - Gregersen, Vivi Raundahl
AU - Maciel, Guilherme de Moura
AU - Madsen, Lone Bruhn
AU - Buitenhuis, Albert Johannes
AU - Stenholt Hansen, Mikka
AU - Bendixen, Christian
AU - Larsen, Lotte Bach
PY - 2017/8/1
Y1 - 2017/8/1
N2 - The effect on rennet-induced milk coagulation of three novel genetic haplotypes in close proximity to CSN3 encoding κ-casein was evaluated. Milk samples were collected from 71 Danish Holstein cows homozygous for the three novel haplotypes named according to which genetic variants of CSN3 they were characterised by: AE, A and B, respectively. The results documented that haplotype AE had significantly longer rennet coagulation time and lower curd firming rate compared with haplotypes A and B. Haplotype AE milk was further characterised by larger casein micelles and lower relative content of κ-casein, whereas the total protein contents did not differ among haplotypes. These findings indicate that the genetic κ-casein A variant can be divided into two groups with poor and good milk coagulation properties. Furthermore, three milk samples were identified as non-coagulating. These were all associated with the haplotype AE.
AB - The effect on rennet-induced milk coagulation of three novel genetic haplotypes in close proximity to CSN3 encoding κ-casein was evaluated. Milk samples were collected from 71 Danish Holstein cows homozygous for the three novel haplotypes named according to which genetic variants of CSN3 they were characterised by: AE, A and B, respectively. The results documented that haplotype AE had significantly longer rennet coagulation time and lower curd firming rate compared with haplotypes A and B. Haplotype AE milk was further characterised by larger casein micelles and lower relative content of κ-casein, whereas the total protein contents did not differ among haplotypes. These findings indicate that the genetic κ-casein A variant can be divided into two groups with poor and good milk coagulation properties. Furthermore, three milk samples were identified as non-coagulating. These were all associated with the haplotype AE.
UR - http://www.scopus.com/inward/record.url?scp=85018526313&partnerID=8YFLogxK
U2 - 10.1016/j.idairyj.2017.03.012
DO - 10.1016/j.idairyj.2017.03.012
M3 - Journal article
SN - 0958-6946
VL - 71
SP - 122
EP - 130
JO - International Dairy Journal
JF - International Dairy Journal
ER -