Novel cardiovascular risk markers in depression: No association between depressive symptoms and osteoprotegerin or adiponectin in persons at high risk for sleep apnea

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

  • Gunnar Einvik
  • ,
  • Allan Flyvbjerg, Danmark
  • Harald Hrubos-Strøm
  • ,
  • Anna Randby
  • ,
  • Jan Frystyk
  • Mette Bjerre
  • Silje K Namtvedt
  • ,
  • Håvard A Kristiansen
  • ,
  • Inger H Nordhus
  • ,
  • Virend K Somers
  • ,
  • Toril Dammen
  • ,
  • Torbjørn Omland
BACKGROUND: Inflammation is believed to play a role in the pathogenesis of both cardiovascular disease and depressive disorders. We hypothesized that circulating concentrations of the novel inflammatory and cardiovascular biomarkers osteoprotegerin (OPG) and adiponectin as well as high sensitivity C-reactive protein (hsCRP) are associated with the severity of depressive symptoms and presence of major depressive disorder (MDD). METHODS: In a cross-sectional population-derived study (Akershus Sleep Apnea Project) 520 persons underwent clinical examination and venous blood sampling. Medical history was obtained and the participants completed the Beck Depression Inventory (BDI). Structured clinical interviews for axis-I disorders including MDD were performed in a subgroup of 288 participants. OPG and adiponectin concentrations were determined by in-house time-resolved immunofluorometric assays. RESULTS: Despite significant correlation with hsCRP (r=0.162, p
TidsskriftJournal of Affective Disorders
StatusUdgivet - 2012

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