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Normative values for region-specific colonic and gastrointestinal transit times in 111 healthy volunteers using the 3D-Transit electromagnet tracking system: Influence of age, gender, and body mass index

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Normative values for region-specific colonic and gastrointestinal transit times in 111 healthy volunteers using the 3D-Transit electromagnet tracking system : Influence of age, gender, and body mass index. / Nandhra, Gursharan Kaur; Mark, Esben Bolvig; Di Tanna, Gian Luca et al.

I: Neurogastroenterology and Motility, Bind 32, Nr. 2, e13734, 02.2020.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avis › Tidsskriftartikel › Forskning › peer review

Harvard

Nandhra, GK, Mark, EB, Di Tanna, GL, Haase, A-M, Poulsen, J, Christodoulides, S, Kung, V, Klinge, MW, Knudsen, K, Borghammer, P, Andersen, KO, Fynne, L, Sutter, N, Schlageter, V, Krogh, K, Drewes, AM, Birch, M & Scott, SM 2020, 'Normative values for region-specific colonic and gastrointestinal transit times in 111 healthy volunteers using the 3D-Transit electromagnet tracking system: Influence of age, gender, and body mass index', Neurogastroenterology and Motility, bind 32, nr. 2, e13734. https://doi.org/10.1111/nmo.13734

APA

Nandhra, G. K., Mark, E. B., Di Tanna, G. L., Haase, A-M., Poulsen, J., Christodoulides, S., Kung, V., Klinge, M. W., Knudsen, K., Borghammer, P., Andersen, K. O., Fynne, L., Sutter, N., Schlageter, V., Krogh, K., Drewes, A. M., Birch, M., & Scott, S. M. (2020). Normative values for region-specific colonic and gastrointestinal transit times in 111 healthy volunteers using the 3D-Transit electromagnet tracking system: Influence of age, gender, and body mass index. Neurogastroenterology and Motility, 32(2), [e13734]. https://doi.org/10.1111/nmo.13734

CBE

Nandhra GK, Mark EB, Di Tanna GL, Haase A-M, Poulsen J, Christodoulides S, Kung V, Klinge MW, Knudsen K, Borghammer P, et al. 2020. Normative values for region-specific colonic and gastrointestinal transit times in 111 healthy volunteers using the 3D-Transit electromagnet tracking system: Influence of age, gender, and body mass index. Neurogastroenterology and Motility. 32(2):Article e13734. https://doi.org/10.1111/nmo.13734

MLA

Nandhra, Gursharan Kaur et al. "Normative values for region-specific colonic and gastrointestinal transit times in 111 healthy volunteers using the 3D-Transit electromagnet tracking system: Influence of age, gender, and body mass index". Neurogastroenterology and Motility. 2020. 32(2). https://doi.org/10.1111/nmo.13734

Vancouver

Nandhra GK, Mark EB, Di Tanna GL, Haase A-M, Poulsen J, Christodoulides S et al. Normative values for region-specific colonic and gastrointestinal transit times in 111 healthy volunteers using the 3D-Transit electromagnet tracking system: Influence of age, gender, and body mass index. Neurogastroenterology and Motility. 2020 feb.;32(2):e13734. doi: 10.1111/nmo.13734

Author

Nandhra, Gursharan Kaur ; Mark, Esben Bolvig ; Di Tanna, Gian Luca et al. / Normative values for region-specific colonic and gastrointestinal transit times in 111 healthy volunteers using the 3D-Transit electromagnet tracking system : Influence of age, gender, and body mass index. I: Neurogastroenterology and Motility. 2020 ; Bind 32, Nr. 2.

Bibtex

@article{0b96ba1953304fdf83b4b6182c13ada9,
title = "Normative values for region-specific colonic and gastrointestinal transit times in 111 healthy volunteers using the 3D-Transit electromagnet tracking system: Influence of age, gender, and body mass index",
abstract = "Background: The 3D-Transit electromagnet tracking system (Motilis Medica, SA, Lausanne, Switzerland) is an emerging tool for the ambulatory assessment of gastrointestinal (GI) transit and motility. Using this tool, we aimed to derive normative values for region-specific colonic and GI transit times and to assess the influence of age, gender, and body mass index (BMI). Methods: Regional and total colonic transit times (CTT), gastric emptying (GET), small intestinal (SITT), and whole gut (WGTT) transit times were extracted from 111 healthy volunteers from the United Kingdom and Denmark (58 female; median age: 40 years [range: 21-88]). The effects of age, gender, and BMI were assessed using standard statistical methods. Key Results: The ascending, transverse, descending, and rectosigmoid colon transit times accounted for 32%, 34%, 17%, and 17% of total CTT in females, and 33%, 25%, 14%, and 28% of total CTT in males. CTT and WGTT were seen to cluster at intervals separated by approximately 24 hours, providing further evidence of the non-continuous nature of these measurements. Increasing age was associated with longer CTT (P =.021), WGTT (P <.001) ascending (P =.004), transverse (P <.001), and total right (P <.001) colon transit times, but shorter rectosigmoid (P =.004) transit time. Female gender was significantly associated with longer transverse (P =.049) and descending (P <.001) colon transit times, but shorter rectosigmoid (P <.001) transit time. Increasing BMI was significantly associated with shorter WGTT (P =.012). Conclusions and Inferences: For the first time, normative reference values for region-specific colonic transit have been presented. Age, gender, and BMI were seen to have an effect on transit times.",
keywords = "colon, gastrointestinal, ingestible capsule, motility, transit time, PRESSURE, GUT TRANSIT, MOVEMENTS, MOTILITY CAPSULE, PH, CLINICAL-ASSESSMENT",
author = "Nandhra, {Gursharan Kaur} and Mark, {Esben Bolvig} and {Di Tanna}, {Gian Luca} and Anne-Mette Haase and Jakob Poulsen and Stephanos Christodoulides and Victor Kung and Klinge, {Mette W} and Karoline Knudsen and Per Borghammer and Andersen, {Katrine O} and Lotte Fynne and Nanna Sutter and Vincent Schlageter and Klaus Krogh and Drewes, {Asbj{\o}rn Mohr} and Malcolm Birch and Scott, {S Mark}",
note = "{\textcopyright} 2019 John Wiley & Sons Ltd.",
year = "2020",
month = feb,
doi = "10.1111/nmo.13734",
language = "English",
volume = "32",
journal = "Neurogastroenterology and Motility",
issn = "1350-1925",
publisher = "Wiley-Blackwell Publishing Ltd.",
number = "2",

}

RIS

TY - JOUR

T1 - Normative values for region-specific colonic and gastrointestinal transit times in 111 healthy volunteers using the 3D-Transit electromagnet tracking system

T2 - Influence of age, gender, and body mass index

AU - Nandhra, Gursharan Kaur

AU - Mark, Esben Bolvig

AU - Di Tanna, Gian Luca

AU - Haase, Anne-Mette

AU - Poulsen, Jakob

AU - Christodoulides, Stephanos

AU - Kung, Victor

AU - Klinge, Mette W

AU - Knudsen, Karoline

AU - Borghammer, Per

AU - Andersen, Katrine O

AU - Fynne, Lotte

AU - Sutter, Nanna

AU - Schlageter, Vincent

AU - Krogh, Klaus

AU - Drewes, Asbjørn Mohr

AU - Birch, Malcolm

AU - Scott, S Mark

N1 - © 2019 John Wiley & Sons Ltd.

PY - 2020/2

Y1 - 2020/2

N2 - Background: The 3D-Transit electromagnet tracking system (Motilis Medica, SA, Lausanne, Switzerland) is an emerging tool for the ambulatory assessment of gastrointestinal (GI) transit and motility. Using this tool, we aimed to derive normative values for region-specific colonic and GI transit times and to assess the influence of age, gender, and body mass index (BMI). Methods: Regional and total colonic transit times (CTT), gastric emptying (GET), small intestinal (SITT), and whole gut (WGTT) transit times were extracted from 111 healthy volunteers from the United Kingdom and Denmark (58 female; median age: 40 years [range: 21-88]). The effects of age, gender, and BMI were assessed using standard statistical methods. Key Results: The ascending, transverse, descending, and rectosigmoid colon transit times accounted for 32%, 34%, 17%, and 17% of total CTT in females, and 33%, 25%, 14%, and 28% of total CTT in males. CTT and WGTT were seen to cluster at intervals separated by approximately 24 hours, providing further evidence of the non-continuous nature of these measurements. Increasing age was associated with longer CTT (P =.021), WGTT (P <.001) ascending (P =.004), transverse (P <.001), and total right (P <.001) colon transit times, but shorter rectosigmoid (P =.004) transit time. Female gender was significantly associated with longer transverse (P =.049) and descending (P <.001) colon transit times, but shorter rectosigmoid (P <.001) transit time. Increasing BMI was significantly associated with shorter WGTT (P =.012). Conclusions and Inferences: For the first time, normative reference values for region-specific colonic transit have been presented. Age, gender, and BMI were seen to have an effect on transit times.

AB - Background: The 3D-Transit electromagnet tracking system (Motilis Medica, SA, Lausanne, Switzerland) is an emerging tool for the ambulatory assessment of gastrointestinal (GI) transit and motility. Using this tool, we aimed to derive normative values for region-specific colonic and GI transit times and to assess the influence of age, gender, and body mass index (BMI). Methods: Regional and total colonic transit times (CTT), gastric emptying (GET), small intestinal (SITT), and whole gut (WGTT) transit times were extracted from 111 healthy volunteers from the United Kingdom and Denmark (58 female; median age: 40 years [range: 21-88]). The effects of age, gender, and BMI were assessed using standard statistical methods. Key Results: The ascending, transverse, descending, and rectosigmoid colon transit times accounted for 32%, 34%, 17%, and 17% of total CTT in females, and 33%, 25%, 14%, and 28% of total CTT in males. CTT and WGTT were seen to cluster at intervals separated by approximately 24 hours, providing further evidence of the non-continuous nature of these measurements. Increasing age was associated with longer CTT (P =.021), WGTT (P <.001) ascending (P =.004), transverse (P <.001), and total right (P <.001) colon transit times, but shorter rectosigmoid (P =.004) transit time. Female gender was significantly associated with longer transverse (P =.049) and descending (P <.001) colon transit times, but shorter rectosigmoid (P <.001) transit time. Increasing BMI was significantly associated with shorter WGTT (P =.012). Conclusions and Inferences: For the first time, normative reference values for region-specific colonic transit have been presented. Age, gender, and BMI were seen to have an effect on transit times.

KW - colon

KW - gastrointestinal

KW - ingestible capsule

KW - motility

KW - transit time

KW - PRESSURE

KW - GUT TRANSIT

KW - MOVEMENTS

KW - MOTILITY CAPSULE

KW - PH

KW - CLINICAL-ASSESSMENT

U2 - 10.1111/nmo.13734

DO - 10.1111/nmo.13734

M3 - Journal article

C2 - 31565841

VL - 32

JO - Neurogastroenterology and Motility

JF - Neurogastroenterology and Motility

SN - 1350-1925

IS - 2

M1 - e13734

ER -