TY - JOUR

T1 - Normal salivary production using a swab method in clinical settings

AU - Møller, Patrick Rønde

AU - Kærsgaard, Mathias Lyngbye

AU - Grydehøj, Jolanta

AU - Ovesen, Therese

N1 - Publisher Copyright: © 2022 The Authors. Clinical Otolaryngology published by John Wiley & Sons Ltd.

PY - 2022/9

Y1 - 2022/9

N2 - Objectives: The purpose of the study was to generate age- and gender-based normative data for unstimulated salivary flow rate (uSFR) by means of a swab method, and to provide preliminary results of using the test in patients suspected of reduced salivary function. Methods: The 130 healthy participants without subjective xerostomia or suspicion of reduced salivation were recruited. Measurements of uSFR were conducted three times per subject and mean uSFR was calculated for the entire population and stratified according to age and gender. The method was applied in a pilot population of 25 patients suffering from either Sjögren's syndrome or had underwent irradiation of the head and neck. Results: Mean uSFR in the healthy group was 0.808 g/min (range: 0.165–2.442). Not significant trends towards declining uSFR with increasing age and higher uSFR in women were seen. Mean uSFR in the patients was 0.429 g/min (range: 0.111–1.448), which was significantly lower than normative values. Use of xerogenic drugs correlated to lower uSFR. Conclusion: Age- and gender-based normative data of uSFR was presented using a fast and readily implementable swab test. The test was able to objectively verify hyposalivation among patients suffering from Sjögren's syndrome or having been exposed to head and neck radiation.

AB - Objectives: The purpose of the study was to generate age- and gender-based normative data for unstimulated salivary flow rate (uSFR) by means of a swab method, and to provide preliminary results of using the test in patients suspected of reduced salivary function. Methods: The 130 healthy participants without subjective xerostomia or suspicion of reduced salivation were recruited. Measurements of uSFR were conducted three times per subject and mean uSFR was calculated for the entire population and stratified according to age and gender. The method was applied in a pilot population of 25 patients suffering from either Sjögren's syndrome or had underwent irradiation of the head and neck. Results: Mean uSFR in the healthy group was 0.808 g/min (range: 0.165–2.442). Not significant trends towards declining uSFR with increasing age and higher uSFR in women were seen. Mean uSFR in the patients was 0.429 g/min (range: 0.111–1.448), which was significantly lower than normative values. Use of xerogenic drugs correlated to lower uSFR. Conclusion: Age- and gender-based normative data of uSFR was presented using a fast and readily implementable swab test. The test was able to objectively verify hyposalivation among patients suffering from Sjögren's syndrome or having been exposed to head and neck radiation.

KW - dry mouth

KW - hyposalivation

KW - salivary flow rate

KW - salivary gland disease

KW - salivary gland dysfunction

KW - xerostomia

UR - http://www.scopus.com/inward/record.url?scp=85134052453&partnerID=8YFLogxK

U2 - 10.1111/coa.13953

DO - 10.1111/coa.13953

M3 - Journal article

C2 - 35724318

AN - SCOPUS:85134052453

VL - 47

SP - 583

EP - 588

JO - Clinical Otolaryngology

JF - Clinical Otolaryngology

SN - 1749-4478

IS - 5

ER -