TY - JOUR
T1 - Nonsense-mediated mRNA decay
T2 - an intricate machinery that shapes transcriptomes
AU - Lykke-Andersen, Søren
AU - Jensen, Torben Heick
PY - 2015/11
Y1 - 2015/11
N2 - Nonsense-mediated mRNA decay (NMD) is probably the best characterized eukaryotic RNA degradation pathway. Through intricate steps, a set of NMD factors recognize and degrade mRNAs with translation termination codons that are positioned in abnormal contexts. However, NMD is not only part of a general cellular quality control system that prevents the production of aberrant proteins. Mammalian cells also depend on NMD to dynamically adjust their transcriptomes and their proteomes to varying physiological conditions. In this Review, we discuss how NMD targets mRNAs, the types of mRNAs that are targeted, and the roles of NMD in cellular stress, differentiation and maturation processes.
AB - Nonsense-mediated mRNA decay (NMD) is probably the best characterized eukaryotic RNA degradation pathway. Through intricate steps, a set of NMD factors recognize and degrade mRNAs with translation termination codons that are positioned in abnormal contexts. However, NMD is not only part of a general cellular quality control system that prevents the production of aberrant proteins. Mammalian cells also depend on NMD to dynamically adjust their transcriptomes and their proteomes to varying physiological conditions. In this Review, we discuss how NMD targets mRNAs, the types of mRNAs that are targeted, and the roles of NMD in cellular stress, differentiation and maturation processes.
UR - http://biorxiv.org/content/early/2016/05/27/055731
U2 - 10.1038/nrm4063
DO - 10.1038/nrm4063
M3 - Journal article
C2 - 26397022
SN - 1471-0072
VL - 16
SP - 665
EP - 677
JO - Nature Reviews. Molecular Cell Biology
JF - Nature Reviews. Molecular Cell Biology
ER -