Non-Ribosomal peptide synthetases in Fusarium species: Genetic and Functional studies

Publikation: Bog/antologi/afhandling/rapportPh.d.-afhandlingForskning

  • Patricia Romans-Fuertes
StatusUdgivet - 11 dec. 2015

Note vedr. afhandling

Fungi have a high impact on our society both in a negative and positive way, due to the ability to produce secondary metabolites. Non-ribosomal peptide synthetases (NRPSs) are multi-modular enzymes responsible for the synthesis of some of these compounds by a mechanism of action which bypasses the ribosomal machinery. These compounds are of a great value due to their bioactive properties, as for example, the cytotoxicity displayed towards some cancer cell lines. Therefore, NRPSs and their products are important targets of study.

During her studies, Patricia researched about NRPSs in two Fusarium species. The first aim of the thesis was the application of molecular approaches to relate the production of some known compounds to possible candidate NRPS genes found in F. graminearum and F. solani. Additionally, a second aim was the elucidation of the protein structure of a partial NRPS found in F. solani to obtain more knowledge about the mechanism of action for these synthetases

The PhD degree was completed at the Department of Molecular Biology and Genetics, Faculty of Science and Technology, Aarhus University.

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