Psykologisk Institut

Non-replication of the association between 5HTTLPR and response to psychological therapy for child anxiety disorders

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

Dokumenter

DOI

  • Kathryn J Lester
  • ,
  • Susanna Roberts
  • ,
  • Robert Keers
  • ,
  • Jonathan R I Coleman
  • ,
  • Gerome Breen
  • ,
  • Chloe C Y Wong, Danmark
  • Xiaohui Xu, Danmark
  • Kristian Arendt
  • ,
  • Judith Blatter-Meunier, Danmark
  • Susan Bögels
  • ,
  • Peter Cooper
  • ,
  • Cathy Creswell
  • ,
  • Einar R Heiervang
  • ,
  • Chantal Herren, Danmark
  • Sanne M Hogendoorn, Danmark
  • Jennifer L Hudson
  • ,
  • Karen Krause, Danmark
  • Heidi J Lyneham
  • ,
  • Anna McKinnon
  • ,
  • Talia Morris
  • ,
  • Maaike H Nauta, Danmark
  • Ronald M Rapee
  • ,
  • Yasmin Rey, Danmark
  • Silvia Schneider
  • ,
  • Sophie C Schneider
  • ,
  • Wendy K Silverman
  • ,
  • Patrick Smith, Danmark
  • Mikael Thastum
  • Kerstin Thirlwall
  • ,
  • Polly Waite
  • ,
  • Gro Janne Wergeland
  • ,
  • Thalia C Eley

BackgroundWe previously reported an association between 5HTTLPR genotype and outcome following cognitive-behavioural therapy (CBT) in child anxiety (Cohort 1). Children homozygous for the low-expression short-allele showed more positive outcomes. Other similar studies have produced mixed results, with most reporting no association between genotype and CBT outcome.AimsTo replicate the association between 5HTTLPR and CBT outcome in child anxiety from the Genes for Treatment study (GxT Cohort 2, n = 829).MethodLogistic and linear mixed effects models were used to examine the relationship between 5HTTLPR and CBT outcomes. Mega-analyses using both cohorts were performed.ResultsThere was no significant effect of 5HTTLPR on CBT outcomes in Cohort 2. Mega-analyses identified a significant association between 5HTTLPR and remission from all anxiety disorders at follow-up (odds ratio 0.45, P = 0.014), but not primary anxiety disorder outcomes.ConclusionsThe association between 5HTTLPR genotype and CBT outcome did not replicate. Short-allele homozygotes showed more positive treatment outcomes, but with small, non-significant effects. Future studies would benefit from utilising whole genome approaches and large, homogenous samples.

OriginalsprogEngelsk
TidsskriftBritish Journal of Psychiatry
Vol/bind208
Nummer2
Sider (fra-til)182-188
Antal sider7
ISSN0007-1250
DOI
StatusUdgivet - 2016

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