Department of Clinical Medicine

TY - JOUR

T1 - Non-pharmacological interventions for preventing weight gain in patients with first episode schizophrenia or bipolar disorder

T2 - A systematic review

AU - Nyboe, Lene

AU - Lemcke, Sanne

AU - Møller, Anne Vils

AU - Stubbs, Brendon

PY - 2019/11

Y1 - 2019/11

N2 - Weight gain is a side effect of antipsychotic medication and highly prevalent in people with schizophrenia or bipolar disorder, increasing their overall cardio-metabolic risk. We conducted a systematic review on non-pharmacological interventions for preventing/reducing weight gain or increase in waist-circumference in young, newly diagnosed patients with schizophrenia or bipolar disorder. We searched major electronic databases from inception to 04/2019 on RCTs, pre- and post-test studies, and non-randomized controlled clinical trials. From a potential of 2963 hits, eight studies met the inclusion criteria (n = 438, mean age of 18.8 (13–45) years). The interventions comprised supervised and individually adjusted aerobic exercise activities (5 studies), individual lifestyle counselling vs. control condition (2 RCTs), and dietetic counselling and practical training of cooking and shopping (1 study). Physical activity and practical dietetic interventions seem to be more efficient than lifestyle counselling. However, the results shall be taken with caution due to the non-randomized designs and other methodologically deficits in the majority of the included studies.

AB - Weight gain is a side effect of antipsychotic medication and highly prevalent in people with schizophrenia or bipolar disorder, increasing their overall cardio-metabolic risk. We conducted a systematic review on non-pharmacological interventions for preventing/reducing weight gain or increase in waist-circumference in young, newly diagnosed patients with schizophrenia or bipolar disorder. We searched major electronic databases from inception to 04/2019 on RCTs, pre- and post-test studies, and non-randomized controlled clinical trials. From a potential of 2963 hits, eight studies met the inclusion criteria (n = 438, mean age of 18.8 (13–45) years). The interventions comprised supervised and individually adjusted aerobic exercise activities (5 studies), individual lifestyle counselling vs. control condition (2 RCTs), and dietetic counselling and practical training of cooking and shopping (1 study). Physical activity and practical dietetic interventions seem to be more efficient than lifestyle counselling. However, the results shall be taken with caution due to the non-randomized designs and other methodologically deficits in the majority of the included studies.

KW - Bipolar disorder

KW - First episode schizophrenia

KW - Non-pharmacological intervention

KW - Prevention

KW - Weight gain

UR - http://www.scopus.com/inward/record.url?scp=85072186425&partnerID=8YFLogxK

U2 - 10.1016/j.psychres.2019.112556

DO - 10.1016/j.psychres.2019.112556

M3 - Review

C2 - 31521840

AN - SCOPUS:85072186425

VL - 281

JO - Psychiatry Research

JF - Psychiatry Research

SN - 0165-1781

M1 - 112556

ER -