Non-infectious rhinitis is more strongly associated with early-rather than late-onset of COPD: data from the European Community Respiratory Health Survey (ECRHS)

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DOI

  • Joel Bergqvist, Univ Gothenburg, University of Gothenburg, Gothenburg Global Biodivers Ctr, Sverige
  • Anders Andersson, Univ Gothenburg, University of Gothenburg, Gothenburg Global Biodivers Ctr, Sverige
  • Linus Schiöler, Univ Gothenburg, University of Gothenburg, Gothenburg Global Biodivers Ctr, Sverige
  • Anna-Carin Olin, Univ Gothenburg, University of Gothenburg, Gothenburg Global Biodivers Ctr, Sverige
  • Nicola Murgia, Univ Gothenburg, University of Gothenburg, Gothenburg Global Biodivers Ctr, Sverige
  • Mogens Bove, Novartis Sweden AB, Stockholm, Sweden., Sverige
  • Christer Janson, Uppsala University and Uppsala Clinical Research Center, Uppsala University, Sweden., Sverige
  • Michael J Abramson, Monash Med Ctr, Monash University, Monash Heart, Australien
  • Bénédicte Leynaert, Inserm UMR1152, Pathophysiology and Epidemiology of Respiratory Diseases, University of Paris, Frankrig
  • Dennis Nowak, Institute and Clinic for Occupational, Social and Environmental Medicine, University Hospital, LMU Munich, Munich, Tyskland
  • Karl A Franklin, Umeå University, Sverige
  • Isabelle Pin, Pneumologie Pédiatrique, Antenne Pédiatrique du CIC, Grenoble, Frankrig
  • Torgeir Storaas, SKS/RAAO-Helse Vest, Haukeland universitetssjukehus, Bergen, Norge
  • Vivi Schlünssen
  • Joachim Heinrich, Institute and Clinic for Occupational, Social and Environmental Medicine, University Hospital, LMU Munich, Munich, Tyskland
  • Johan Hellgren, Univ Gothenburg, University of Gothenburg, Gothenburg Global Biodivers Ctr, Sverige

PURPOSE: Chronic obstructive pulmonary disease (COPD) is associated with several co-morbidities and non-infectious rhinitis (NIR) has emerged as a new possible co-morbidity. The primary aim of this study is to confirm a previously reported association between NIR and COPD in a multicentre population over time. The secondary aim is to investigate the course over time of such an association through a comparison between early- and late-onset COPD.

METHODS: This study is part of the European Community Respiratory Health Survey (ECRHS). A random adult population from 25 centres in Europe and one in Australia was examined with spirometry and answered a respiratory questionnaire in 1998-2002 (ECRHS II) and in 2008-2013 (ECRHS III). Symptoms of non-infectious rhinitis, hay fever and asthma, and smoking habits were reported. Subjects reporting asthma were excluded. COPD was defined as a spirometry ratio of FEV1/FVC < 0.7. A total of 5901 subjects were included.

RESULTS: Non-infectious rhinitis was significantly more prevalent in subjects with COPD compared with no COPD (48.9% vs 37.1%, p < 0.001) in ECRHS II (mean age 43) but not in ECHRS III (mean age 54). In the multivariable regression model adjusted for COPD, smoking, age, BMI, and gender, non-infectious rhinitis was associated with COPD in both ECRHS II and III.

CONCLUSION: Non-infectious rhinitis was significantly more common in subjects with COPD at a mean age of 43. Ten years later, the association was weaker. The findings indicate that NIR could be associated with the early onset of COPD.

OriginalsprogEngelsk
TidsskriftEuropean Archives of Oto-Rhino-Laryngology
Vol/bind277
Nummer5
Sider (fra-til)1353-1359
Antal sider7
ISSN0937-4477
DOI
StatusUdgivet - maj 2020

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