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New hallmarks of ageing: a 2022 Copenhagen ageing meeting summary

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avis › Tidsskriftartikel › Forskning › peer review

Dokumenter

DOI

  • Tomas Schmauck-Medina, University of Oslo
    • ,
  • Adrian Molière, University of Oslo
    • ,
  • Sofie Lautrup, University of Oslo
    • ,
  • Jianying Zhang, University of Oslo
    • ,
  • Stefan Chlopicki, Universitet Jagielloński
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  • Helena Borland Madsen, Københavns Universitet
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  • Shuqin Cao, University of Oslo
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  • Casper Soendenbroe, Københavns Universitet
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  • Els Mansell, Lund University, University College London
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  • Mark Bitsch Vestergaard, Københavns Universitet
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  • Zhiquan Li, Københavns Universitet
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  • Yosef Shiloh, Tel Aviv University
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  • Patricia L. Opresko, University of Pittsburgh
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  • Jean Marc Egly, Université de Strasbourg, National Taiwan University
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  • Thomas Kirkwood, Københavns Universitet, Newcastle University
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  • Eric Verdin, Buck Institute for Age Research
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  • Vilhelm A. Bohr, Københavns Universitet, National Institute on Aging
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  • Lynne S. Cox, University of Oxford
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  • Tinna Stevnsner
  • Lene Juel Rasmussen, Københavns Universitet
    • ,
  • Evandro F. Fang, University of Oslo, The Norwegian Centre on Healthy Ageing (NO-Age)

Genomic instability, telomere attrition, epigenetic alterations, mitochondrial dysfunction, loss of proteostasis, deregulated nutrient-sensing, cellular senescence, stem cell exhaustion, and altered intercellular communication were the original nine hallmarks of ageing proposed by López-Otín and colleagues in 2013. The proposal of these hallmarks of ageing has been instrumental in guiding and pushing forward research on the biology of ageing. In the nearly past 10 years, our in-depth exploration on ageing research has enabled us to formulate new hallmarks of ageing which are compromised autophagy, microbiome disturbance, altered mechanical properties, splicing dysregulation, and inflammation, among other emerging ones. Amalgamation of the ‘old’ and ‘new’ hallmarks of ageing may provide a more comprehensive explanation of ageing and age-related diseases, shedding light on interventional and therapeutic studies to achieve healthy, happy, and productive lives in the elderly.

OriginalsprogEngelsk
TidsskriftAging
Vol/bind14
Nummer16
Sider (fra-til)6829-6839
Antal sider11
ISSN1945-4589
DOI
StatusUdgivet - aug. 2022

Bibliografisk note

Funding Information:
We thank Novo Nordisk Foundation for financial and catering supports. Partial materials used to generate Figure 1 were from BioRender subscribed by the Fang laboratory.

Publisher Copyright:
© 2022 Schmauck-Medina et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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