Neurocognitive function and health-related quality of life in a nationwide cohort of long-term childhood brain tumor survivors

Anne Sophie Lind Helligsø; Louise Tram Henriksen; Line Kenborg; Yasmin Alexandra Lassen; Lisa Maria Wu; Jeanette Falck Winther; Henrik Hasle; Ali Amidi

doi:10.1093/nop/npac085

Neurocognitive function and health-related quality of life in a nationwide cohort of long-term childhood brain tumor survivors

Anne Sophie Lind Helligsø^*, Louise Tram Henriksen, Line Kenborg, Yasmin Alexandra Lassen, Lisa Maria Wu, Jeanette Falck Winther, Henrik Hasle, Ali Amidi

^*Corresponding author af dette arbejde

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avis › Tidsskriftartikel › Forskning › peer review

4 Citationer (Scopus)

Abstract

BACKGROUND: Childhood brain tumor survivors are at high risk of late effects, especially neurocognitive impairment. Limited data are available examining neurocognitive function and associations with quality of life (QoL) in childhood brain tumor survivors. Our aim was to examine neurocognitive function in childhood brain tumor survivors, and associations with QoL and symptom burden.

METHODS: Five-year survivors of brain tumors over the age of 15 were identified in the Danish Childhood Cancer Registry ( n = 423). Eligible and consenting participants completed neuropsychological tests and questionnaires assessing QoL, insomnia, fatigue, anxiety, and depression. Survivors treated with radiation ( n = 59) were statistically compared with survivors not treated with radiation ( n = 102).

RESULTS: In total, 170 survivors participated (40.2% participation rate). Sixty-six percent of the survivors who completed neurocognitive tests ( n = 161) exhibited overall neurocognitive impairment. Survivors treated with radiation, especially whole-brain irradiation, exhibited poorer neurocognitive outcomes than survivors not treated with radiation. Neurocognitive outcomes for survivors treated with surgery were below normative expectations. Furthermore, a number of survivors experienced significant fatigue (40%), anxiety (23%), insomnia (13%), and/or depression (6%). Survivors treated with radiation reported lower quality of life (QoL) and higher symptom burden scores than survivors not treated with radiation; particularly in physical functioning, and social functioning with symptoms of fatigue. Neurocognitive impairment was not associated with QoL or symptom burden.

CONCLUSIONS: In this study, a majority of the childhood brain tumor survivors experienced neurocognitive impairment, reduced QoL, and high symptom burden. Although not associated with each other, it is apparent that childhood brain tumor survivors experience not only neurocognitive dysfunction but may also experience QoL impairments and significant symptom burden.

Originalsprog	Engelsk
Tidsskrift	Neuro-Oncology Practice
Vol/bind	10
Nummer	2
Sider (fra-til)	140–151
Antal sider	12
ISSN	2054-2577
DOI	https://doi.org/10.1093/nop/npac085
Status	Udgivet - 1 apr. 2023

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10.1093/nop/npac085

https://pmc.ncbi.nlm.nih.gov/articles/PMC10037941/pdf/npac085.pdf

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title = "Neurocognitive function and health-related quality of life in a nationwide cohort of long-term childhood brain tumor survivors",

abstract = "BACKGROUND: Childhood brain tumor survivors are at high risk of late effects, especially neurocognitive impairment. Limited data are available examining neurocognitive function and associations with quality of life (QoL) in childhood brain tumor survivors. Our aim was to examine neurocognitive function in childhood brain tumor survivors, and associations with QoL and symptom burden.METHODS: Five-year survivors of brain tumors over the age of 15 were identified in the Danish Childhood Cancer Registry ( n = 423). Eligible and consenting participants completed neuropsychological tests and questionnaires assessing QoL, insomnia, fatigue, anxiety, and depression. Survivors treated with radiation ( n = 59) were statistically compared with survivors not treated with radiation ( n = 102). RESULTS: In total, 170 survivors participated (40.2% participation rate). Sixty-six percent of the survivors who completed neurocognitive tests ( n = 161) exhibited overall neurocognitive impairment. Survivors treated with radiation, especially whole-brain irradiation, exhibited poorer neurocognitive outcomes than survivors not treated with radiation. Neurocognitive outcomes for survivors treated with surgery were below normative expectations. Furthermore, a number of survivors experienced significant fatigue (40%), anxiety (23%), insomnia (13%), and/or depression (6%). Survivors treated with radiation reported lower quality of life (QoL) and higher symptom burden scores than survivors not treated with radiation; particularly in physical functioning, and social functioning with symptoms of fatigue. Neurocognitive impairment was not associated with QoL or symptom burden. CONCLUSIONS: In this study, a majority of the childhood brain tumor survivors experienced neurocognitive impairment, reduced QoL, and high symptom burden. Although not associated with each other, it is apparent that childhood brain tumor survivors experience not only neurocognitive dysfunction but may also experience QoL impairments and significant symptom burden.",

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author = "Helligs{\o}, {Anne Sophie Lind} and Henriksen, {Louise Tram} and Line Kenborg and Lassen, {Yasmin Alexandra} and Wu, {Lisa Maria} and Winther, {Jeanette Falck} and Henrik Hasle and Ali Amidi",

year = "2023",

month = apr,

day = "1",

doi = "10.1093/nop/npac085",

language = "English",

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Neurocognitive function and health-related quality of life in a nationwide cohort of long-term childhood brain tumor survivors. / Helligsø, Anne Sophie Lind; Henriksen, Louise Tram; Kenborg, Line et al.
I: Neuro-Oncology Practice, Bind 10, Nr. 2, 01.04.2023, s. 140–151.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avis › Tidsskriftartikel › Forskning › peer review

TY - JOUR

T1 - Neurocognitive function and health-related quality of life in a nationwide cohort of long-term childhood brain tumor survivors

AU - Helligsø, Anne Sophie Lind

AU - Henriksen, Louise Tram

AU - Kenborg, Line

AU - Lassen, Yasmin Alexandra

AU - Wu, Lisa Maria

AU - Winther, Jeanette Falck

AU - Hasle, Henrik

AU - Amidi , Ali

PY - 2023/4/1

Y1 - 2023/4/1

N2 - BACKGROUND: Childhood brain tumor survivors are at high risk of late effects, especially neurocognitive impairment. Limited data are available examining neurocognitive function and associations with quality of life (QoL) in childhood brain tumor survivors. Our aim was to examine neurocognitive function in childhood brain tumor survivors, and associations with QoL and symptom burden.METHODS: Five-year survivors of brain tumors over the age of 15 were identified in the Danish Childhood Cancer Registry ( n = 423). Eligible and consenting participants completed neuropsychological tests and questionnaires assessing QoL, insomnia, fatigue, anxiety, and depression. Survivors treated with radiation ( n = 59) were statistically compared with survivors not treated with radiation ( n = 102). RESULTS: In total, 170 survivors participated (40.2% participation rate). Sixty-six percent of the survivors who completed neurocognitive tests ( n = 161) exhibited overall neurocognitive impairment. Survivors treated with radiation, especially whole-brain irradiation, exhibited poorer neurocognitive outcomes than survivors not treated with radiation. Neurocognitive outcomes for survivors treated with surgery were below normative expectations. Furthermore, a number of survivors experienced significant fatigue (40%), anxiety (23%), insomnia (13%), and/or depression (6%). Survivors treated with radiation reported lower quality of life (QoL) and higher symptom burden scores than survivors not treated with radiation; particularly in physical functioning, and social functioning with symptoms of fatigue. Neurocognitive impairment was not associated with QoL or symptom burden. CONCLUSIONS: In this study, a majority of the childhood brain tumor survivors experienced neurocognitive impairment, reduced QoL, and high symptom burden. Although not associated with each other, it is apparent that childhood brain tumor survivors experience not only neurocognitive dysfunction but may also experience QoL impairments and significant symptom burden.

AB - BACKGROUND: Childhood brain tumor survivors are at high risk of late effects, especially neurocognitive impairment. Limited data are available examining neurocognitive function and associations with quality of life (QoL) in childhood brain tumor survivors. Our aim was to examine neurocognitive function in childhood brain tumor survivors, and associations with QoL and symptom burden.METHODS: Five-year survivors of brain tumors over the age of 15 were identified in the Danish Childhood Cancer Registry ( n = 423). Eligible and consenting participants completed neuropsychological tests and questionnaires assessing QoL, insomnia, fatigue, anxiety, and depression. Survivors treated with radiation ( n = 59) were statistically compared with survivors not treated with radiation ( n = 102). RESULTS: In total, 170 survivors participated (40.2% participation rate). Sixty-six percent of the survivors who completed neurocognitive tests ( n = 161) exhibited overall neurocognitive impairment. Survivors treated with radiation, especially whole-brain irradiation, exhibited poorer neurocognitive outcomes than survivors not treated with radiation. Neurocognitive outcomes for survivors treated with surgery were below normative expectations. Furthermore, a number of survivors experienced significant fatigue (40%), anxiety (23%), insomnia (13%), and/or depression (6%). Survivors treated with radiation reported lower quality of life (QoL) and higher symptom burden scores than survivors not treated with radiation; particularly in physical functioning, and social functioning with symptoms of fatigue. Neurocognitive impairment was not associated with QoL or symptom burden. CONCLUSIONS: In this study, a majority of the childhood brain tumor survivors experienced neurocognitive impairment, reduced QoL, and high symptom burden. Although not associated with each other, it is apparent that childhood brain tumor survivors experience not only neurocognitive dysfunction but may also experience QoL impairments and significant symptom burden.

KW - childhood brain tumor survivors

KW - health-related quality of life

KW - neurocognition

KW - symptom burden

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U2 - 10.1093/nop/npac085

DO - 10.1093/nop/npac085

M3 - Journal article

C2 - 36970169

SN - 2054-2577

VL - 10

SP - 140

EP - 151

JO - Neuro-Oncology Practice

JF - Neuro-Oncology Practice

IS - 2

ER -

Neurocognitive function and health-related quality of life in a nationwide cohort of long-term childhood brain tumor survivors

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