Nanoscale E-Cadherin ligand patterns show threshold size for cellular adhesion and adherence junction formation

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The role of ligand spatial distribution on the formation of cadherin mediated cell-cell contacts is studied utilizing nanopatterns of E-cadherin ligands. Protein patches ranging in size from 100 nm to 800 nm prepared by colloidal lithography critically influence adhesion, spreading and formation of adherence junctions in epithelial cells. Cells at 100 nm patterns show poor adhesion, while larger pattern sizes show both good adhesion, significant spreading and defined cortical actin. We estimate a threshold of 0.03μm2 for epithelial cellular attachment via E-Cadherin
OriginalsprogEngelsk
TidsskriftNano Letters
Vol/bind12
Nummer4
Sider (fra-til)2129–2133
Antal sider5
ISSN1530-6984
DOI
StatusUdgivet - 2012

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