Myocardial and Peripheral Ischemia Causes an Increase in Circulating Pregnancy-Associated Plasma Protein-A in Non-atherosclerotic, Non-heparinized Pigs

Lasse Bach Steffensen; Christian Bo Poulsen; Jeong Shim; Marie Bek; Kevin Jacobsen; Cheryl A Conover; Jacob Fog Bentzon; Claus Oxvig

doi:10.1007/s12265-015-9656-y

Myocardial and Peripheral Ischemia Causes an Increase in Circulating Pregnancy-Associated Plasma Protein-A in Non-atherosclerotic, Non-heparinized Pigs

Lasse Bach Steffensen, Christian Bo Poulsen, Jeong Shim, Marie Bek, Kevin Jacobsen, Cheryl A Conover, Jacob Fog Bentzon, Claus Oxvig

Institut for Klinisk Medicin - Hjertesygdomme

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avis › Tidsskriftartikel › Forskning › peer review

1 Citationer (Scopus)

Abstract

The usefulness of circulating pregnancy-associated plasma protein-A (PAPP-A) as a biomarker for acute coronary syndrome (ACS) is widely debated. We used the pig as a model to assess PAPP-A dynamics in the setting of myocardial ischemia. Induction of myocardial ischemia by ligation of the left anterior descending (LAD) coronary artery caused a systemic rise in PAPP-A. However, the ischemic myocardium was excluded as the source of PAPP-A. Interestingly, induction of ischemia in peripheral tissues by ligation of the left femoral artery caused a systemic rise in PAPP-A originating from the left hind limb. This is the first study to demonstrate PAPP-A elevations in the absence of atherosclerosis or heparin during myocardial ischemia. Our findings thus add to the current discussion of the usefulness of PAPP-A as a biomarker for ACS.

Originalsprog	Engelsk
Tidsskrift	Journal of Cardiovascular Translational Research
Vol/bind	8
Nummer	9
Sider (fra-til)	528-535
Antal sider	8
ISSN	1937-5387
DOI	https://doi.org/10.1007/s12265-015-9656-y
Status	Udgivet - 2015

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10.1007/s12265-015-9656-y

http://download.springer.com/static/pdf/479/art%253A10.1007%252Fs12265-015-9656-y.pdf?originUrl=http%3A%2F%2Flink.springer.com%2Farticle%2F10.1007%2Fs12265-015-9656-y&token2=exp=1455097906~acl=%2Fstatic%2Fpdf%2F479%2Fart%25253A10.1007%25252Fs12265-015-9656-y.pdf%3ForiginUrl%3Dhttp%253A%252F%252Flink.springer.com%252Farticle%252F10.1007%252Fs12265-015-9656-y*~hmac=eec79ab6c58d8295f020d44ba733c6a495c1eab3098a0aa8cb75e733494a737c

Citationsformater

Steffensen, L. B., Poulsen, C. B., Shim, J., Bek, M., Jacobsen, K., Conover, C. A., Bentzon, J. F., & Oxvig, C. (2015). Myocardial and Peripheral Ischemia Causes an Increase in Circulating Pregnancy-Associated Plasma Protein-A in Non-atherosclerotic, Non-heparinized Pigs. Journal of Cardiovascular Translational Research, 8(9), 528-535. https://doi.org/10.1007/s12265-015-9656-y

@article{bb9a27930f344efea89982afca2c9393,

title = "Myocardial and Peripheral Ischemia Causes an Increase in Circulating Pregnancy-Associated Plasma Protein-A in Non-atherosclerotic, Non-heparinized Pigs",

abstract = "The usefulness of circulating pregnancy-associated plasma protein-A (PAPP-A) as a biomarker for acute coronary syndrome (ACS) is widely debated. We used the pig as a model to assess PAPP-A dynamics in the setting of myocardial ischemia. Induction of myocardial ischemia by ligation of the left anterior descending (LAD) coronary artery caused a systemic rise in PAPP-A. However, the ischemic myocardium was excluded as the source of PAPP-A. Interestingly, induction of ischemia in peripheral tissues by ligation of the left femoral artery caused a systemic rise in PAPP-A originating from the left hind limb. This is the first study to demonstrate PAPP-A elevations in the absence of atherosclerosis or heparin during myocardial ischemia. Our findings thus add to the current discussion of the usefulness of PAPP-A as a biomarker for ACS.",

author = "Steffensen, {Lasse Bach} and Poulsen, {Christian Bo} and Jeong Shim and Marie Bek and Kevin Jacobsen and Conover, {Cheryl A} and Bentzon, {Jacob Fog} and Claus Oxvig",

year = "2015",

doi = "10.1007/s12265-015-9656-y",

language = "English",

volume = "8",

pages = "528--535",

journal = "Journal of Cardiovascular Translational Research",

issn = "1937-5387",

publisher = "Springer",

number = "9",

}

Steffensen, LB, Poulsen, CB, Shim, J, Bek, M, Jacobsen, K, Conover, CA, Bentzon, JF & Oxvig, C 2015, 'Myocardial and Peripheral Ischemia Causes an Increase in Circulating Pregnancy-Associated Plasma Protein-A in Non-atherosclerotic, Non-heparinized Pigs', Journal of Cardiovascular Translational Research, bind 8, nr. 9, s. 528-535. https://doi.org/10.1007/s12265-015-9656-y

Myocardial and Peripheral Ischemia Causes an Increase in Circulating Pregnancy-Associated Plasma Protein-A in Non-atherosclerotic, Non-heparinized Pigs. / Steffensen, Lasse Bach; Poulsen, Christian Bo; Shim, Jeong et al.
I: Journal of Cardiovascular Translational Research, Bind 8, Nr. 9, 2015, s. 528-535.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avis › Tidsskriftartikel › Forskning › peer review

TY - JOUR

T1 - Myocardial and Peripheral Ischemia Causes an Increase in Circulating Pregnancy-Associated Plasma Protein-A in Non-atherosclerotic, Non-heparinized Pigs

AU - Steffensen, Lasse Bach

AU - Poulsen, Christian Bo

AU - Shim, Jeong

AU - Bek, Marie

AU - Jacobsen, Kevin

AU - Conover, Cheryl A

AU - Bentzon, Jacob Fog

AU - Oxvig, Claus

PY - 2015

Y1 - 2015

N2 - The usefulness of circulating pregnancy-associated plasma protein-A (PAPP-A) as a biomarker for acute coronary syndrome (ACS) is widely debated. We used the pig as a model to assess PAPP-A dynamics in the setting of myocardial ischemia. Induction of myocardial ischemia by ligation of the left anterior descending (LAD) coronary artery caused a systemic rise in PAPP-A. However, the ischemic myocardium was excluded as the source of PAPP-A. Interestingly, induction of ischemia in peripheral tissues by ligation of the left femoral artery caused a systemic rise in PAPP-A originating from the left hind limb. This is the first study to demonstrate PAPP-A elevations in the absence of atherosclerosis or heparin during myocardial ischemia. Our findings thus add to the current discussion of the usefulness of PAPP-A as a biomarker for ACS.

AB - The usefulness of circulating pregnancy-associated plasma protein-A (PAPP-A) as a biomarker for acute coronary syndrome (ACS) is widely debated. We used the pig as a model to assess PAPP-A dynamics in the setting of myocardial ischemia. Induction of myocardial ischemia by ligation of the left anterior descending (LAD) coronary artery caused a systemic rise in PAPP-A. However, the ischemic myocardium was excluded as the source of PAPP-A. Interestingly, induction of ischemia in peripheral tissues by ligation of the left femoral artery caused a systemic rise in PAPP-A originating from the left hind limb. This is the first study to demonstrate PAPP-A elevations in the absence of atherosclerosis or heparin during myocardial ischemia. Our findings thus add to the current discussion of the usefulness of PAPP-A as a biomarker for ACS.

U2 - 10.1007/s12265-015-9656-y

DO - 10.1007/s12265-015-9656-y

M3 - Journal article

C2 - 26443031

SN - 1937-5387

VL - 8

SP - 528

EP - 535

JO - Journal of Cardiovascular Translational Research

JF - Journal of Cardiovascular Translational Research

IS - 9

ER -

Myocardial and Peripheral Ischemia Causes an Increase in Circulating Pregnancy-Associated Plasma Protein-A in Non-atherosclerotic, Non-heparinized Pigs

Abstract

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