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Mussel Inspired Polynorepinephrine Functionalized Electrospun Polycaprolactone Microfibers for Muscle Regeneration
Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avis › Tidsskriftartikel › Forskning › peer review
Dokumenter
- s41598-017-08572-z
Forlagets udgivne version, 2,99 MB, PDF-dokument
DOI
- https://doi.org/10.1038/s41598-017-08572-z
Forlagets udgivne version
- Ying Liu, CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology and Institute of High Energy Physics, Beijing, China. Electronic address: liuy@nanoctr.cn., Danmark
- Guoqiang Zhou, Hebei University ,
- Zhu Liu, National Center for Nanoscience and Technology (NCNST), Beijing, Hebei University ,
- Mengyu Guo, National Center for Nanoscience and Technology (NCNST), Beijing ,
- Xiumei Jiang, National Center for Nanoscience and Technology (NCNST), Beijing ,
- Mehmet Berat Taskin ,
- Zhongyang Zhang ,
- Jing Liu, National Center for Nanoscience and Technology (NCNST), Beijing ,
- Jinglong Tang, National Center for Nanoscience and Technology (NCNST), Beijing ,
- Ru Bai, National Center for Nanoscience and Technology (NCNST), Beijing ,
- Flemming Besenbacher
- Menglin Chen
- Chunying Chen, CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology and Institute of High Energy Physics, Beijing, China. Electronic address: chenchy@nanoctr.cn.
Electrospun scaffolds with excellent mechanical properties, high specific surface area and a commendable porous network are widely used in tissue engineering. Improving the hydrophilicity and cell adhesion of hydrophobic substrates is the key point to enhance the effectiveness of electrospun scaffolds. In this study, polycaprolactone (PCL) fibrous membranes with appropriate diameter were selected and coated by mussel-inspired poly norepinephrine (pNE). And norepinephrine is a catecholamine functioning as a hormone and neurotransmitter in the human brain. The membrane with smaller diameter fibers, a relative larger specific surface area and the suitable pNE functionalization provided more suitable microenvironment for cell adhesion and proliferation both in vitro and in vivo. The regenerated muscle layer can be integrated well with fibrous membranes and surrounding tissues at the impaired site and thus the mechanical strength reached the value of native tissue. The underlying molecular mechanism is mediated via inhibiting myostatin expression by PI3K/AKT/mTOR hypertrophy pathway. The properly functionalized fibrous membranes hold the potential for repairing muscle injuries. Our current work also provides an insight for rational design and development of better tissue engineering materials for skeletal muscle regeneration.
| Originalsprog | Engelsk |
|---|---|
| Artikelnummer | 8197 |
| Tidsskrift | Scientific Reports |
| Vol/bind | 7 |
| Nummer | 1 |
| Sider (fra-til) | 8197 |
| Antal sider | 10 |
| ISSN | 2045-2322 |
| DOI | |
| Status | Udgivet - 2017 |
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