TY - JOUR
T1 - Muscle damage and repeated bout effect following blood flow restricted exercise
AU - Sieljacks, Peter
AU - Matzon, Andreas
AU - Wernbom, Mathias
AU - Ringgaard, Steffen
AU - Vissing, Kristian
AU - Overgaard, Kristian
PY - 2016/3
Y1 - 2016/3
N2 - Purpose: Blood-flow restricted resistance exercise training (BFRE) is suggested to be effective in rehabilitation training, but more knowledge is required about its potential muscle damaging effects. Therefore, we investigated muscle-damaging effects of BFRE performed to failure and possible protective effects of previous bouts of BFRE or maximal eccentric exercise (ECC). Methods: Seventeen healthy young men were allocated into two groups completing two exercise bouts separated by 14 days. One group performed BFRE in both exercise bouts (BB). The other group performed ECC in the first and BFRE in the second bout. BFRE was performed to failure. Indicators of muscle damage were evaluated before and after exercise. Results: The first bout in the BB group led to decrements in maximum isometric torque, and increases in muscle soreness, muscle water retention, and serum muscle protein concentrations after exercise. These changes were comparable in magnitude and time course to what was observed after first bout ECC. An attenuated response was observed in the repeated exercise bout in both groups. Conclusion: We conclude that unaccustomed single-bout BFRE performed to failure induces significant muscle damage. Additionally, both ECC and BFRE can precondition against muscle damage induced by a subsequent bout of BFRE.
AB - Purpose: Blood-flow restricted resistance exercise training (BFRE) is suggested to be effective in rehabilitation training, but more knowledge is required about its potential muscle damaging effects. Therefore, we investigated muscle-damaging effects of BFRE performed to failure and possible protective effects of previous bouts of BFRE or maximal eccentric exercise (ECC). Methods: Seventeen healthy young men were allocated into two groups completing two exercise bouts separated by 14 days. One group performed BFRE in both exercise bouts (BB). The other group performed ECC in the first and BFRE in the second bout. BFRE was performed to failure. Indicators of muscle damage were evaluated before and after exercise. Results: The first bout in the BB group led to decrements in maximum isometric torque, and increases in muscle soreness, muscle water retention, and serum muscle protein concentrations after exercise. These changes were comparable in magnitude and time course to what was observed after first bout ECC. An attenuated response was observed in the repeated exercise bout in both groups. Conclusion: We conclude that unaccustomed single-bout BFRE performed to failure induces significant muscle damage. Additionally, both ECC and BFRE can precondition against muscle damage induced by a subsequent bout of BFRE.
KW - blood flow occlusion
KW - eccentric resistance training
KW - muscle wasting
KW - preconditioning
KW - repeated bout effect
UR - http://www.scopus.com/inward/record.url?scp=84958040661&partnerID=8YFLogxK
U2 - 10.1007/s00421-015-3304-8
DO - 10.1007/s00421-015-3304-8
M3 - Journal article
C2 - 26645685
SN - 1439-6319
VL - 116
SP - 513
EP - 525
JO - European Journal of Applied Physiology
JF - European Journal of Applied Physiology
IS - 3
ER -