Molecular imprinting of complex matrices at localized surface plasmon resonance biosensors for screening of global interactions of polyphenols and proteins

Joana Rafaela Guerreiro; Vladimir Bochenkov; Kasper Savskov Runager; Hüsnü Aslan; Mingdong Dong; Jan J. Enghild; Victor De Freitas; Maria Goreti Ferreira Sales; Duncan Sutherland

doi:10.1021/acssensors.5b00054

Molecular imprinting of complex matrices at localized surface plasmon resonance biosensors for screening of global interactions of polyphenols and proteins

Joana Rafaela Guerreiro, Vladimir Bochenkov, Kasper Savskov Runager, Hüsnü Aslan, Mingdong Dong, Jan J. Enghild, Victor De Freitas, Maria Goreti Ferreira Sales, Duncan Sutherland

Interdisciplinary Nanoscience Center - INANO-Fysik, iNANO-huset

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avis › Tidsskriftartikel › Forskning › peer review

33 Citationer (Scopus)

Abstract

Molecular imprinting polymers (MIP) have been applied to capture and stabilize complex protein matrices at plasmonic sensor surfaces. Ultrathin MIP layers at the surface of gold nanodisks enable the label free quantification of global interactions of polyphenols with protein mixtures. Separate polyphenols (catechin, procyanidin B3- catechin dimer, and PGG-pentagalloyl glucose) give specific and different binding levels to the MIP supported saliva plasmonic sensor. The demonstrated biosensor has application to study bioavailability of polyphenols or evaluation of local retention of small drug molecules.

Originalsprog	Engelsk
Tidsskrift	ACS Sensors
Vol/bind	1
Nummer	3
Sider (fra-til)	258-264
Antal sider	7
DOI	https://doi.org/10.1021/acssensors.5b00054
Status	Udgivet - 25 mar. 2016

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Guerreiro, J. R., Bochenkov, V., Runager, K. S., Aslan, H., Dong, M., Enghild, J. J., De Freitas, V., Sales, M. G. F., & Sutherland, D. (2016). Molecular imprinting of complex matrices at localized surface plasmon resonance biosensors for screening of global interactions of polyphenols and proteins. ACS Sensors, 1(3), 258-264. https://doi.org/10.1021/acssensors.5b00054

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title = "Molecular imprinting of complex matrices at localized surface plasmon resonance biosensors for screening of global interactions of polyphenols and proteins",

abstract = "Molecular imprinting polymers (MIP) have been applied to capture and stabilize complex protein matrices at plasmonic sensor surfaces. Ultrathin MIP layers at the surface of gold nanodisks enable the label free quantification of global interactions of polyphenols with protein mixtures. Separate polyphenols (catechin, procyanidin B3- catechin dimer, and PGG-pentagalloyl glucose) give specific and different binding levels to the MIP supported saliva plasmonic sensor. The demonstrated biosensor has application to study bioavailability of polyphenols or evaluation of local retention of small drug molecules.",

keywords = "biosensing, complex protein matrix, localized surface plasmon resonance (LSPR), molecular imprinting, nanodisks, polyphenols",

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year = "2016",

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doi = "10.1021/acssensors.5b00054",

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Molecular imprinting of complex matrices at localized surface plasmon resonance biosensors for screening of global interactions of polyphenols and proteins. / Guerreiro, Joana Rafaela; Bochenkov, Vladimir; Runager, Kasper Savskov et al.
I: ACS Sensors, Bind 1, Nr. 3, 25.03.2016, s. 258-264.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avis › Tidsskriftartikel › Forskning › peer review

TY - JOUR

T1 - Molecular imprinting of complex matrices at localized surface plasmon resonance biosensors for screening of global interactions of polyphenols and proteins

AU - Guerreiro, Joana Rafaela

AU - Bochenkov, Vladimir

AU - Runager, Kasper Savskov

AU - Aslan, Hüsnü

AU - Dong, Mingdong

AU - Enghild, Jan J.

AU - De Freitas, Victor

AU - Sales, Maria Goreti Ferreira

AU - Sutherland, Duncan

PY - 2016/3/25

Y1 - 2016/3/25

N2 - Molecular imprinting polymers (MIP) have been applied to capture and stabilize complex protein matrices at plasmonic sensor surfaces. Ultrathin MIP layers at the surface of gold nanodisks enable the label free quantification of global interactions of polyphenols with protein mixtures. Separate polyphenols (catechin, procyanidin B3- catechin dimer, and PGG-pentagalloyl glucose) give specific and different binding levels to the MIP supported saliva plasmonic sensor. The demonstrated biosensor has application to study bioavailability of polyphenols or evaluation of local retention of small drug molecules.

AB - Molecular imprinting polymers (MIP) have been applied to capture and stabilize complex protein matrices at plasmonic sensor surfaces. Ultrathin MIP layers at the surface of gold nanodisks enable the label free quantification of global interactions of polyphenols with protein mixtures. Separate polyphenols (catechin, procyanidin B3- catechin dimer, and PGG-pentagalloyl glucose) give specific and different binding levels to the MIP supported saliva plasmonic sensor. The demonstrated biosensor has application to study bioavailability of polyphenols or evaluation of local retention of small drug molecules.

KW - biosensing

KW - complex protein matrix

KW - localized surface plasmon resonance (LSPR)

KW - molecular imprinting

KW - nanodisks

KW - polyphenols

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U2 - 10.1021/acssensors.5b00054

DO - 10.1021/acssensors.5b00054

M3 - Journal article

SN - 2379-3694

VL - 1

SP - 258

EP - 264

JO - ACS Sensors

JF - ACS Sensors

IS - 3

ER -

Molecular imprinting of complex matrices at localized surface plasmon resonance biosensors for screening of global interactions of polyphenols and proteins

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