Molecular characterization and temporal expression profiling of presenilins in the developing porcine brain

Lone B Madsen, Bo Thomsen, Knud Erik Larsen, Christian Bendixen, Ida E Holm, Merete Fredholm, Arne L Jørgensen, Anders L Nielsen, Anders Lade Nielsen

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    Abstract

    The transmembrane presenilin (PSEN) proteins, PSEN1 and PSEN2, have been proposed to be the catalytic components of the gamma-secretase protein complex, which is an intramembranous multimeric protease involved in development, cell regulatory processes, and neurodegeneration in Alzheimer's disease. Here we describe the sequencing, chromosomal mapping, and polymorphism analysis of PSEN1 and PSEN2 in the domestic pig (Sus scrofa domesticus).
    OriginalsprogEngelsk
    TidsskriftB M C Neuroscience
    Vol/bind8
    Nummer72
    Sider (fra-til)1-11
    Antal sider11
    ISSN1471-2202
    DOI
    StatusUdgivet - 1 jan. 2007

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