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Modulation of the fungal mycobiome is regulated by the chitin-binding receptor FIBCD1

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Standard

Modulation of the fungal mycobiome is regulated by the chitin-binding receptor FIBCD1. / Moeller, Jesper B.; Leonardi, Irina; Schlosser, Anders; Flamar, Anne Laure; Bessman, Nicholas J.; Putzel, Gregory Garbès; Thomsen, Theresa; Hammond, Mark; Jepsen, Christine S.; Skjødt, Karsten; Füchtbauer, Ernst Martin; Farber, Donna L.; Sorensen, Grith L.; Iliev, Iliyan D.; Holmskov, Uffe; Artis, David.

I: The Journal of Experimental Medicine, Bind 216, Nr. 12, 12.2019, s. 2689-2700.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

Harvard

Moeller, JB, Leonardi, I, Schlosser, A, Flamar, AL, Bessman, NJ, Putzel, GG, Thomsen, T, Hammond, M, Jepsen, CS, Skjødt, K, Füchtbauer, EM, Farber, DL, Sorensen, GL, Iliev, ID, Holmskov, U & Artis, D 2019, 'Modulation of the fungal mycobiome is regulated by the chitin-binding receptor FIBCD1', The Journal of Experimental Medicine, bind 216, nr. 12, s. 2689-2700. https://doi.org/10.1084/jem.20182244

APA

Moeller, J. B., Leonardi, I., Schlosser, A., Flamar, A. L., Bessman, N. J., Putzel, G. G., Thomsen, T., Hammond, M., Jepsen, C. S., Skjødt, K., Füchtbauer, E. M., Farber, D. L., Sorensen, G. L., Iliev, I. D., Holmskov, U., & Artis, D. (2019). Modulation of the fungal mycobiome is regulated by the chitin-binding receptor FIBCD1. The Journal of Experimental Medicine, 216(12), 2689-2700. https://doi.org/10.1084/jem.20182244

CBE

Moeller JB, Leonardi I, Schlosser A, Flamar AL, Bessman NJ, Putzel GG, Thomsen T, Hammond M, Jepsen CS, Skjødt K, Füchtbauer EM, Farber DL, Sorensen GL, Iliev ID, Holmskov U, Artis D. 2019. Modulation of the fungal mycobiome is regulated by the chitin-binding receptor FIBCD1. The Journal of Experimental Medicine. 216(12):2689-2700. https://doi.org/10.1084/jem.20182244

MLA

Moeller, Jesper B. o.a.. "Modulation of the fungal mycobiome is regulated by the chitin-binding receptor FIBCD1". The Journal of Experimental Medicine. 2019, 216(12). 2689-2700. https://doi.org/10.1084/jem.20182244

Vancouver

Moeller JB, Leonardi I, Schlosser A, Flamar AL, Bessman NJ, Putzel GG o.a. Modulation of the fungal mycobiome is regulated by the chitin-binding receptor FIBCD1. The Journal of Experimental Medicine. 2019 dec;216(12):2689-2700. https://doi.org/10.1084/jem.20182244

Author

Moeller, Jesper B. ; Leonardi, Irina ; Schlosser, Anders ; Flamar, Anne Laure ; Bessman, Nicholas J. ; Putzel, Gregory Garbès ; Thomsen, Theresa ; Hammond, Mark ; Jepsen, Christine S. ; Skjødt, Karsten ; Füchtbauer, Ernst Martin ; Farber, Donna L. ; Sorensen, Grith L. ; Iliev, Iliyan D. ; Holmskov, Uffe ; Artis, David. / Modulation of the fungal mycobiome is regulated by the chitin-binding receptor FIBCD1. I: The Journal of Experimental Medicine. 2019 ; Bind 216, Nr. 12. s. 2689-2700.

Bibtex

@article{c9535729b09443b294093b9a84355c44,
title = "Modulation of the fungal mycobiome is regulated by the chitin-binding receptor FIBCD1",
abstract = "Host-microbiota interactions are critical in regulating mammalian health and disease. In addition to bacteria, parasites, and viruses, beneficial communities of fungi (the mycobiome) are important modulators of immune- and tissue-homeostasis. Chitin is a major component of the fungal cell wall, and fibrinogen C containing domain 1 (FIBCD1) is a chitin-binding protein; however, the role of this molecule in influencing host-mycobiome interactions in vivo has never been examined. Here, we identify direct binding of FIBCD1 to intestinal-derived fungi and demonstrate that epithelial-specific expression of FIBCD1 results in significantly reduced fungal colonization and amelioration of fungal-driven intestinal inflammation. Collectively, these results identify FIBCD1 as a previously unrecognized microbial pattern recognition receptor through which intestinal epithelial cells can recognize and control fungal colonization, limit fungal dysbiosis, and dampen intestinal inflammation.",
author = "Moeller, {Jesper B.} and Irina Leonardi and Anders Schlosser and Flamar, {Anne Laure} and Bessman, {Nicholas J.} and Putzel, {Gregory Garb{\`e}s} and Theresa Thomsen and Mark Hammond and Jepsen, {Christine S.} and Karsten Skj{\o}dt and F{\"u}chtbauer, {Ernst Martin} and Farber, {Donna L.} and Sorensen, {Grith L.} and Iliev, {Iliyan D.} and Uffe Holmskov and David Artis",
year = "2019",
month = dec,
doi = "10.1084/jem.20182244",
language = "English",
volume = "216",
pages = "2689--2700",
journal = "Journal of Experimental Medicine",
issn = "0022-1007",
publisher = "Rockefeller University Press",
number = "12",

}

RIS

TY - JOUR

T1 - Modulation of the fungal mycobiome is regulated by the chitin-binding receptor FIBCD1

AU - Moeller, Jesper B.

AU - Leonardi, Irina

AU - Schlosser, Anders

AU - Flamar, Anne Laure

AU - Bessman, Nicholas J.

AU - Putzel, Gregory Garbès

AU - Thomsen, Theresa

AU - Hammond, Mark

AU - Jepsen, Christine S.

AU - Skjødt, Karsten

AU - Füchtbauer, Ernst Martin

AU - Farber, Donna L.

AU - Sorensen, Grith L.

AU - Iliev, Iliyan D.

AU - Holmskov, Uffe

AU - Artis, David

PY - 2019/12

Y1 - 2019/12

N2 - Host-microbiota interactions are critical in regulating mammalian health and disease. In addition to bacteria, parasites, and viruses, beneficial communities of fungi (the mycobiome) are important modulators of immune- and tissue-homeostasis. Chitin is a major component of the fungal cell wall, and fibrinogen C containing domain 1 (FIBCD1) is a chitin-binding protein; however, the role of this molecule in influencing host-mycobiome interactions in vivo has never been examined. Here, we identify direct binding of FIBCD1 to intestinal-derived fungi and demonstrate that epithelial-specific expression of FIBCD1 results in significantly reduced fungal colonization and amelioration of fungal-driven intestinal inflammation. Collectively, these results identify FIBCD1 as a previously unrecognized microbial pattern recognition receptor through which intestinal epithelial cells can recognize and control fungal colonization, limit fungal dysbiosis, and dampen intestinal inflammation.

AB - Host-microbiota interactions are critical in regulating mammalian health and disease. In addition to bacteria, parasites, and viruses, beneficial communities of fungi (the mycobiome) are important modulators of immune- and tissue-homeostasis. Chitin is a major component of the fungal cell wall, and fibrinogen C containing domain 1 (FIBCD1) is a chitin-binding protein; however, the role of this molecule in influencing host-mycobiome interactions in vivo has never been examined. Here, we identify direct binding of FIBCD1 to intestinal-derived fungi and demonstrate that epithelial-specific expression of FIBCD1 results in significantly reduced fungal colonization and amelioration of fungal-driven intestinal inflammation. Collectively, these results identify FIBCD1 as a previously unrecognized microbial pattern recognition receptor through which intestinal epithelial cells can recognize and control fungal colonization, limit fungal dysbiosis, and dampen intestinal inflammation.

UR - http://www.scopus.com/inward/record.url?scp=85075960076&partnerID=8YFLogxK

U2 - 10.1084/jem.20182244

DO - 10.1084/jem.20182244

M3 - Journal article

C2 - 31601676

AN - SCOPUS:85075960076

VL - 216

SP - 2689

EP - 2700

JO - Journal of Experimental Medicine

JF - Journal of Experimental Medicine

SN - 0022-1007

IS - 12

ER -