Mitochondrial helicases and mitochondrial genome maintenance

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisReviewForskningpeer review

  • Maria Diget Aamann, Danmark
  • Nadja C de Souza-Pinto
  • ,
  • Tomasz Kulikowicz
  • ,
  • Tinna V Stevnsner
  • Vilhelm A Bohr, Danmark
  • Molekylærbiologisk Institut
  • Dansk Center for Molekylær Gerontologi
Helicases are essential enzymes that utilize the energy of nucleotide hydrolysis to drive unwinding of nucleic acid duplexes. Helicases play roles in all aspects of DNA metabolism including DNA repair, DNA replication and transcription. The subcellular locations and functions of several helicases have been studied in detail; however, the roles of specific helicases in mitochondrial biology remain poorly characterized. This review presents important recent advances in identifying and characterizing mitochondrial helicases, some of which also operate in the nucleus.
OriginalsprogEngelsk
TidsskriftMechanisms of Ageing and Development
Vol/bind131
Nummer7-8
Sider (fra-til)503-10
Antal sider8
ISSN0047-6374
DOI
StatusUdgivet - 2010

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