miRConnect 2.0: identification of oncogenic, antagonistic miRNA families in three human cancers

TY - JOUR

T1 - miRConnect 2.0

T2 - identification of oncogenic, antagonistic miRNA families in three human cancers

AU - Hua, Youjia

AU - Larsen, Niels

AU - Kalyana-Sundaram, Shanker

AU - Kjems, Jørgen

AU - Chinnaiyan, Arul M

AU - Peter, Marcus E

PY - 2013/3/15

Y1 - 2013/3/15

N2 - Based on their function in cancer micro(mi)RNAs are often grouped as either tumor suppressors or oncogenes. However, miRNAs regulate multiple tumor relevant signaling pathways raising the question whether two oncogenic miRNAs could be functional antagonists by promoting different steps in tumor progression. We recently developed a method to connect miRNAs to biological function by comparing miRNA and gene array expression data from the NCI60 cell lines without using miRNA target predictions (miRConnect).

AB - Based on their function in cancer micro(mi)RNAs are often grouped as either tumor suppressors or oncogenes. However, miRNAs regulate multiple tumor relevant signaling pathways raising the question whether two oncogenic miRNAs could be functional antagonists by promoting different steps in tumor progression. We recently developed a method to connect miRNAs to biological function by comparing miRNA and gene array expression data from the NCI60 cell lines without using miRNA target predictions (miRConnect).

KW - Carcinoma, Renal Cell

KW - Cell Line, Tumor

KW - Cluster Analysis

KW - Epithelial-Mesenchymal Transition

KW - Female

KW - Gene Expression Profiling

KW - Gene Expression Regulation, Neoplastic

KW - Glioblastoma

KW - Humans

KW - Kidney Neoplasms

KW - MicroRNAs

KW - Neoplasms

KW - Oncogenes

KW - Ovarian Neoplasms

KW - RNA, Messenger

U2 - 10.1186/1471-2164-14-179

DO - 10.1186/1471-2164-14-179

M3 - Journal article

C2 - 23497354

SN - 1471-2164

VL - 14

SP - 1

EP - 18

JO - B M C Genomics

JF - B M C Genomics

IS - 179

ER -