miRConnect 2.0: identification of oncogenic, antagonistic miRNA families in three human cancers

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  • Youjia Hua, Feinberg School of Medicine, Division Hematology/Oncology, Northwestern University, USA
  • Niels Larsen
  • Shanker Kalyana-Sundaram, 3 Michigan Center for Translational Pathology, USA
  • Jørgen Kjems
  • Arul M Chinnaiyan, Michigan Center for Translational Pathology, USA
  • Marcus E Peter, Feinberg School of Medicine, Division Hematology/Oncology, Northwestern University, USA
Based on their function in cancer micro(mi)RNAs are often grouped as either tumor suppressors or oncogenes. However, miRNAs regulate multiple tumor relevant signaling pathways raising the question whether two oncogenic miRNAs could be functional antagonists by promoting different steps in tumor progression. We recently developed a method to connect miRNAs to biological function by comparing miRNA and gene array expression data from the NCI60 cell lines without using miRNA target predictions (miRConnect).
OriginalsprogEngelsk
TidsskriftB M C Genomics
Vol/bind14
Nummer179
Sider (fra-til)1-18
Antal sider18
ISSN1471-2164
DOI
StatusUdgivet - 15 mar. 2013

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