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miR-155 as a Biomarker in B-Cell Malignancies
Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avis › Tidsskriftartikel › Forskning › peer review
DOI
- https://doi.org/10.1155/2016/9513037
Forlagets udgivne version
- Hanne Due ,
- Pernille Svendsen, Aalborg Universitet ,
- Julie Støve Bødker, Aalborg Universitet ,
- Alexander Schmitz
- Martin Bøgsted
- Hans Erik Johnsen, Aalborg Universitet ,
- Tarec Christoffer El-Galaly, Aalborg Universitet ,
- Anne Stidsholt Roug
- Karen Dybkær, Aalborg Universitet
MicroRNAs have the potential to be useful biomarkers in the development of individualized treatment since they are easy to detect, are relatively stable during sample handling, and are important determinants of cellular processes controlling pathogenesis, progression, and response to treatment of several types of cancers including B-cell malignancies. miR-155 is an oncomiR with a crucial role in tumor initiation and development of several B-cell malignancies. The present review elucidates the potential of miR-155 as a diagnostic, prognostic, or predictive biomarker in B-cell malignancies using a systematic search strategy to identify relevant literature. miR-155 was upregulated in several malignancies compared to nonmalignant controls and overexpression of miR-155 was further associated with poor prognosis. Elevated expression of miR-155 shows potential as a diagnostic and prognostic biomarker in diffuse large B-cell lymphoma and chronic lymphocytic leukemia. Additionally, in vitro and in vivo studies suggest miR-155 as an efficient therapeutic target, supporting its oncogenic function. The use of inhibiting anti-miR structures indicates promising potential as novel anticancer therapeutics. Reports from 53 studies prove that miR-155 has the potential to be a molecular tool in personalized medicine.
| Originalsprog | Engelsk |
|---|---|
| Tidsskrift | BioMed Research International |
| Vol/bind | 2016 |
| Sider (fra-til) | 9513037 |
| ISSN | 2314-6133 |
| DOI | |
| Status | Udgivet - 2016 |
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