Mining of lethal recessive genetic variation in Danish cattle

Publikation: Bog/antologi/afhandling/rapportPh.d.-afhandlingForskning

  • Ashutosh Das, Danmark
The widespread use of artificial insemination in cattle breeding Worldwide leads to reduced effective population sizes and increased inbreeding levels. Increased inbreeding result in increased probalility of expression of recessive defective alleles, which probably is reflected in a decline in fertility. The primary objective of this PhD projekt was to identify recessive lethal gentic variants in the main Danish dairy cattle breed. Holstein-Friesian utilzing next generation sequencing (NGS) data. This study shows a potential for the use of the NGS-based reverse genetic approach in identifying lethal or semi-lethal recessive gentic variation
OriginalsprogEngelsk
Antal sider187
ISBN (Trykt)978-87-93398-07-8
StatusUdgivet - 10 dec. 2015

Note vedr. afhandling

The occurrence of harmful mutations in the commercial cattle population has increased due to increased inbreeding. Although the Holstein breed is the main Danish cattle breed, harmful mutations have been identified as a consequence of inbreeding.
In his PhD studies, Ashutosh Das mined harmful mutations in Danish cattle using a next-generation sequencing (NGS)-based reverse genetic approach. He identified five potential harmful mutations in the Danish Holstein cattle breed.
The new research findings provide a potential for the use of NGS-based reverse genetic approach in identifying harmful mutations in cattle.

The PhD degree was completed at the Department of Molecular Biology and Genetics (MBG), Science and Technology, Aarhus University.

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