Mind the gap:: molecular architecture of the axon initial segment – from fold prediction to a mechanistic model of function?

Esben Meldgaard Høgh Quistgaard; Josephine Dannersø Nissen; Sean Hansen; Poul Nissen

doi:10.1016/j.jmb.2021.167176

Mind the gap: molecular architecture of the axon initial segment – from fold prediction to a mechanistic model of function?

Esben Meldgaard Høgh Quistgaard, Josephine Dannersø Nissen, Sean Hansen, Poul Nissen^*

^*Corresponding author af dette arbejde

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avis › Review › Forskning › peer review

7 Citationer (Scopus)

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Abstract

The axon initial segment (AIS) is a distinct neuronal domain, which is responsible for initiating action potentials, and therefore of key importance to neuronal signaling. To determine how it functions, it is necessary to establish which proteins reside there, how they are organized, and what the dynamic features are. Great strides have been made in recent years, and it is now clear that several AIS cytoskeletal and membrane proteins interact to form a higher-order periodic structure. Here we briefly describe AIS function, protein composition and molecular architecture, and discuss perspectives for future structural characterization, and if structure predictions will be able to model complex higher-order assemblies.

Originalsprog	Engelsk
Artikelnummer	167176
Tidsskrift	Journal of Molecular Biology
Vol/bind	433
Nummer	20
Antal sider	8
ISSN	0022-2836
DOI	https://doi.org/10.1016/j.jmb.2021.167176
Status	Udgivet - 1 okt. 2021

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10.1016/j.jmb.2021.167176Licens: CC BY

1-s2.0-S0022283621004095-mainForlagets udgivne version, 1,05 MBLicens: CC BY

Citationsformater

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title = "Mind the gap:: molecular architecture of the axon initial segment – from fold prediction to a mechanistic model of function?",

abstract = "The axon initial segment (AIS) is a distinct neuronal domain, which is responsible for initiating action potentials, and therefore of key importance to neuronal signaling. To determine how it functions, it is necessary to establish which proteins reside there, how they are organized, and what the dynamic features are. Great strides have been made in recent years, and it is now clear that several AIS cytoskeletal and membrane proteins interact to form a higher-order periodic structure. Here we briefly describe AIS function, protein composition and molecular architecture, and discuss perspectives for future structural characterization, and if structure predictions will be able to model complex higher-order assemblies.",

keywords = "action potentials, ankyrin-spectrin, axon initial segment (AIS), membrane ultrastructure, voltage-gated ion channels",

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Mind the gap: molecular architecture of the axon initial segment – from fold prediction to a mechanistic model of function? / Quistgaard, Esben Meldgaard Høgh; Nissen, Josephine Dannersø ; Hansen, Sean et al.
I: Journal of Molecular Biology, Bind 433, Nr. 20, 167176, 01.10.2021.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avis › Review › Forskning › peer review

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AU - Quistgaard, Esben Meldgaard Høgh

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AU - Hansen, Sean

AU - Nissen, Poul

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N2 - The axon initial segment (AIS) is a distinct neuronal domain, which is responsible for initiating action potentials, and therefore of key importance to neuronal signaling. To determine how it functions, it is necessary to establish which proteins reside there, how they are organized, and what the dynamic features are. Great strides have been made in recent years, and it is now clear that several AIS cytoskeletal and membrane proteins interact to form a higher-order periodic structure. Here we briefly describe AIS function, protein composition and molecular architecture, and discuss perspectives for future structural characterization, and if structure predictions will be able to model complex higher-order assemblies.

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KW - action potentials

KW - ankyrin-spectrin

KW - axon initial segment (AIS)

KW - membrane ultrastructure

KW - voltage-gated ion channels

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Mind the gap: molecular architecture of the axon initial segment – from fold prediction to a mechanistic model of function?

Abstract

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