Microvascular dysfunction is associated with plasma osteoprotegerin levels in patients with acute myocardial infarction

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

  • Brian B Løgstrup
  • ,
  • Dan E Høfsten
  • ,
  • Thomas B Christophersen
  • ,
  • Jacob E Møller, Danmark
  • Mette Bjerre
  • Allan Flyvbjerg, Danmark
  • Hans E Bøtker
  • Kenneth Egstrup
OBJECTIVE: Osteoprotegerin (OPG) is a glycoprotein that inhibits nuclear factor-κB's regulatory effects on inflammation, skeletal, and vascular systems, and is a potential biomarker of atherosclerosis and seems to be involved in vascular calcifications. The objective of this study was to assess the relationship between OPG, left ventricular function, and microvascular function in patients with acute myocardial infarction (AMI). PATIENTS AND METHODS: After successful revascularization, noninvasive assessment of coronary flow reserve (CFR) was performed in the distal part of the left anterior descending artery in 183 patients with first AMI. We performed low-dose dobutamine stress echocardiography to assess viability and finally we assessed the ventriculoarterial coupling (VAC). Plasma OPG was determined by ELISA. RESULTS: Plasma OPG concentrations were higher in patients with impaired microcirculation (CFR
OriginalsprogEngelsk
TidsskriftCoronary Artery Disease
ISSN0954-6928
DOI
StatusUdgivet - 15 jun. 2013

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