Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avis › Tidsskriftartikel › Forskning › peer review
Methylation specific Multiplex Ligation-dependent Probe Amplification : utility for prenatal diagnosis of parental origin in human triploidy. / Joergensen, M W; Rasmussen, A A; Niemann, I et al.
I: Prenatal Diagnosis, Bind 33, Nr. 12, 24.07.2013, s. 1131-1136.Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avis › Tidsskriftartikel › Forskning › peer review
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TY - JOUR
T1 - Methylation specific Multiplex Ligation-dependent Probe Amplification
T2 - utility for prenatal diagnosis of parental origin in human triploidy
AU - Joergensen, M W
AU - Rasmussen, A A
AU - Niemann, I
AU - Hindkjaer, J
AU - Agerholm, I
AU - Bolund, Lars
AU - Kolvraa, S
AU - Sunde, L
N1 - This article is protected by copyright. All rights reserved.
PY - 2013/7/24
Y1 - 2013/7/24
N2 - When a triploid pregnancy is diagnosed prenatally, gynaecologists have traditionally relied on the histopathological examination of the tissue from the terminated pregnancy to determine if the pregnancy is molar. However, reproducibility is poor and variability is high when diagnosing hydatidiform moles. Triploid pregnancies can have either the chromosomal constitution of two maternal and one paternal set or two paternal and one maternal set but only the conceptuses with two paternal sets have the potential to cause maternal complications. Therefore it would be beneficial to introduce a method that gives the gynaecologist the parental origin of the genome of the triploid conceptus as early as possible, without delaying the process by first collecting parental samples.
AB - When a triploid pregnancy is diagnosed prenatally, gynaecologists have traditionally relied on the histopathological examination of the tissue from the terminated pregnancy to determine if the pregnancy is molar. However, reproducibility is poor and variability is high when diagnosing hydatidiform moles. Triploid pregnancies can have either the chromosomal constitution of two maternal and one paternal set or two paternal and one maternal set but only the conceptuses with two paternal sets have the potential to cause maternal complications. Therefore it would be beneficial to introduce a method that gives the gynaecologist the parental origin of the genome of the triploid conceptus as early as possible, without delaying the process by first collecting parental samples.
U2 - 10.1002/pd.4206
DO - 10.1002/pd.4206
M3 - Journal article
C2 - 23881788
VL - 33
SP - 1131
EP - 1136
JO - Prenatal Diagnosis
JF - Prenatal Diagnosis
SN - 0197-3851
IS - 12
ER -