Meta-analysis of genome-wide association data identifies a risk locus for major mood disorders on 3p21.1

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  • Francis J McMahon
  • ,
  • Nirmala Akula
  • ,
  • Thomas G Schulze
  • ,
  • Pierandrea Muglia
  • ,
  • Federica Tozzi
  • ,
  • Sevilla D Detera-Wadleigh
  • ,
  • C J M Steele
  • ,
  • René Breuer
  • ,
  • Jana Strohmaier
  • ,
  • Jens R Wendland
  • ,
  • Manuel Mattheisen
  • Thomas W Mühleisen
  • ,
  • Wolfgang Maier
  • ,
  • Markus M Nöthen
  • ,
  • Sven Cichon
  • ,
  • Anne Farmer
  • ,
  • John B Vincent
  • ,
  • Florian Holsboer
  • ,
  • Martin Preisig
  • ,
  • Marcella Rietschel
  • ,
  • Bipolar Disorder Genome Study (BiGS) Consortium
The major mood disorders, which include bipolar disorder and major depressive disorder (MDD), are considered heritable traits, although previous genetic association studies have had limited success in robustly identifying risk loci. We performed a meta-analysis of five case-control cohorts for major mood disorder, including over 13,600 individuals genotyped on high-density SNP arrays. We identified SNPs at 3p21.1 associated with major mood disorders (rs2251219, P = 3.63 x 10(-8); odds ratio = 0.87; 95% confidence interval, 0.83-0.92), with supportive evidence for association observed in two out of three independent replication cohorts. These results provide an example of a shared genetic susceptibility locus for bipolar disorder and MDD.
OriginalsprogEngelsk
TidsskriftNature Genetics
Vol/bind42
Nummer2
Sider (fra-til)128-31
Antal sider4
ISSN1061-4036
DOI
StatusUdgivet - feb. 2010
Eksternt udgivetJa

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